6764-13-2Relevant articles and documents
A method for preparing [...]
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Paragraph 0026, (2017/03/14)
The invention discloses a preparation method of quetiapine hemifumarate. The preparation method of quetiapine hemifumarate comprises the following steps: etherifying, hydrogenating, condensing and carrying out chlorination by taking o-chloronitrobenzene and thiophenol as raw materials, and finally salifying with fumaric acid, thereby obtaining quetiapine hemifumarate. The production technology is simple to operate and convenient for large-scale production, the cost is saved and the high-purity high-yield quetiapine hemifumarate can be obtained.
Phase-Transfer-Catalyzed Gomberg-Bachmann Synthesis of Unsymmetrical Biarenes: A Survey of Catalysts and Substrates
Beadle, James R.,Korzeniowsky, Stephen H.,Rosenberg, David E.,Garcia-Slanga, Blanche J.,Gokel, George W.
, p. 1594 - 1603 (2007/10/02)
Two problems have hindered the Gomberg-Bachmann (GB) and Pschorr reactions of arenediazonium cations: the instability of the arenediazonium salts and side reactions.Arenediazonium tetrafluoroborate and hexafluorophosphate salts can be prepared in high yield and purity and can be stored safely.Unfortunately, these salts are insoluble in most nonpolar organic solvents.Crown ether complexation or other phase-transfer (pt) catalytic methodology can ameliorate this situation, and reactions conducted by the approaches outlined herein often afforded coupling or cyclization products in high yield and corresponding purity.The use of crown ethers, quarternary 'onium salts, lipophilic carboxylic acid salts, and even the polar cosolvent acetonitrile increase the utility of the ptGB reaction dramatically.Sixty examples of couplings are reported along with an assessment of selectivities.A number of examples are also presented of phase-transfer-type Pschorr cyclizations.In the latter case, the use of potassium superoxide, KO2, is introduced to suppress indazole formation.