67648-61-7

Basic information

• Product Name: 2-(4-HYDROXYPHENOXY)PROPIONIC ACID
• Synonyms: 2-(4-hydroxyphenoxy)propanoic acid;propanoic acid, 2-(4-hydroxyphenoxy)-;TIMTEC-BB SBB006616;2-(4-HYDROXYPHENOXY)PROPIONIC ACID;2-(p-Hydroxyphenoxy)propionic acid;2-(4-Hydroxyphenoxy)propionic acid,98%
• CAS NO: 67648-61-7
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.17
• Product Categories: C9;Carbonyl Compounds;Carboxylic Acids
• Mol File: 67648-61-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 143-146 °C(lit.)
• Boiling Point: 275.56°C (rough estimate)
• Flash Point: 151.3 °C
• Appearance: white to light beige crystalline powder
• Density: 1.2481 (rough estimate)
• Vapor Pressure: 4.76E-06mmHg at 25°C
• Refractive Index: 1.4345 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Sparingly)
• CAS DataBase Reference: 2-(4-HYDROXYPHENOXY)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-HYDROXYPHENOXY)PROPIONIC ACID(67648-61-7)
• EPA Substance Registry System: 2-(4-HYDROXYPHENOXY)PROPIONIC ACID(67648-61-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 67648-61-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light beige crystalline powder

Uses

2-(4-Hydroxyphenoxy)propanoic Acid is a component in a cosmetic formulation including fatty acids, which has skin-lightening properties. 2-(4-Hydroxyphenoxy)propanoic Acid is also used in another cosmetic formulation, which gives rise to the reduction of signs of skin aging, wrinkles and UV damaged skin when applied topically.

InChI:InChI=1/C9H10O4/c1-6(9(11)12)13-8-4-2-7(10)3-5-8/h2-6,10H,1H3,(H,11,12)/p-1/t6-/m0/s1

Upstream product

• 13794-15-5 2-(4-methoxyphenoxy)propanoic acid 
• 65343-67-1 ethyl 2-(4-hydroxyphenoxy)propanoate 
• 103-16-2 4-Benzyloxyphenol 
• 63650-08-8 (+)-ethyl 2-(4-benzyloxyphenoxy)propionate 
• 37067-27-9 hydroquinone sulphate potassium salt 
• 108-95-2 phenol 
• 1634-04-4 tert-butyl methyl ether 
• 69033-92-7 2-(4-Methoxyphenoxy)propionsaeuremethylester 

Downstream Products

• 92723-51-8 2-(4-Isopropoxy-phenoxy)-propionic acid 
• 99761-32-7 2-(4-Ethoxy-phenoxy)-propionic acid 
• 91555-67-8 2-(4-Propoxy-phenoxy)-propionic acid 
• 60074-23-9 2-{4-[(5-chloro-2-pyridyl)oxy]phenoxy}propionic acid 
• 76578-20-6 D-2-[p-[(6-chloro-2-quinolyl)oxy]phenoxy]-propionic acid 
• 445041-75-8 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy} propionic acid 
• 60075-04-9 (RS)-methyl 2-(4-hydroxyphenoxy)propionate 
• 142095-62-3 2-(4-(5-chloro-3-nitropyridin-2-yloxy)phenoxy)propionic acid 
• 122008-77-9 2-(4-(2'-fluoro-4'-cyanophenoxy)phenoxy)propionic acid 

Relevant articles and documents

Microbial deracemization of α-substituted carboxylic acids: Substrate specificity and mechanistic investigation

A new enzymatic method for the preparation of optically active α-substituted carboxylic acids is reported. This technique is called deracemization reaction, which provides us with a route to obtain the enantiomerically pure compounds, theoretically in 100% yield starting from the racemic mixture. This means that the synthesis of a racemate is almost equal to the synthesis of the optically active compound, and this concept is entirely different from the commonly accepted one in the asymmetric synthesis. Using the growing cell system of Nocardia diaphanozonaria JCM3208, racemates of 2-aryl- and 2-aryloxypropanoic acid are deracemized smoothly and (R)-form-enriched products are recovered in high chemical yield (>50%). In addition, using optically active starting compounds and deuterated derivatives as well as inhibitors, we have disclosed the fact that a new type of enzyme takes part in this biotransformation, and that the reaction proceeds probably via the same mechanism as that in rat liver.

(2-quinoxalinyloxy) phenoxypropanoic acids and related derivatives as anticancer agents

This invention relates to (2-quinoxalinyloxy)phenoxypropanoic acids, related derivatives thereof, enantiomeric and diastereomeric forms thereof, mixtures of enantiomeric diastereomeric forms thereof, and pharmaceutically acceptable salt forms thereof, pharmaceutical compositions containing them, processes for their preparation, and methods of using them to treat cancer, particularly solid tumors, in mammals.

Synthesis of 2-(4-hydroxyphenoxy)alkanoic acids

A method for synthesizing 2-(4-hydroxyphenoxy)alkanoic acids by reacting a hydroxyaromatic ketone derivative with a 2-substituted alkanoic acid under basic conditions and thereafter oxidizing the intermediate with subsequent hydrolysis.