6767-29-9

Basic information

• Product Name: Benzeneacetic acid, 4-(diMethylaMino)-, Methyl ester
• Synonyms: Benzeneacetic acid, 4-(diMethylaMino)-, Methyl ester;Methyl 2-(4-(dimethylamino)phenyl)acetate
• CAS NO: 6767-29-9
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 6767-29-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetic acid, 4-(diMethylaMino)-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 4-(diMethylaMino)-, Methyl ester(6767-29-9)
• EPA Substance Registry System: Benzeneacetic acid, 4-(diMethylaMino)-, Methyl ester(6767-29-9)

Safety Data

• Hazardous Substances Data: 6767-29-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 17078-28-3 2-[4-(dimethylamino)phenyl]acetic acid 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 96-34-4 methyl chloroacetate 
• 1197-55-3 4-aminophenylacetic acid 
• 74-88-4 methyl iodide 
• 50438-75-0 2-(4-dimethylaminophenyl)ethyl alcohol 
• 39552-81-3 methyl p-aminophenylacetate 

Downstream Products

• 100133-14-0 (4-dimethylamino-phenyl)-acetic acid hydrazide 
• 51337-18-9 {4-[2,2-Bis-(4-methoxy-phenyl)-vinyl]-phenyl}-dimethyl-amine 
• 51337-19-0 {4-[2,2-Bis-(4-ethoxy-phenyl)-vinyl]-phenyl}-dimethyl-amine 
• 99067-96-6 4-(dimethylamino)benzylisocyanate 
• 51337-20-3 {4-[2,2-Bis-(4-methoxy-phenyl)-ethyl]-phenyl}-dimethyl-amine 
• 51337-21-4 {4-[2,2-Bis-(4-ethoxy-phenyl)-ethyl]-phenyl}-dimethyl-amine 
• 259191-69-0 5-(4-Dimethylamino-benzyl)-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 
• 949168-20-1 methyl 5-chloro-2-(4-dimethylaminophenyl)pentanoate 

Relevant articles and documents

Additive-freeN-methylation of amines with methanol over supported iridium catalyst

An efficient and versatile zinc oxide-supported iridium (Ir/ZnO) catalyst was developed to catalyze the additive-freeN-methylation of amines with methanol. Mechanistic studies suggested that the high catalytic reactivity is rooted in the small sizes (1.4 nm) of Ir nanoparticles and the high ratio (93%) of oxidized iridium species (IrOx, Ir3+and Ir4+) on the catalyst. Moreover, the delicate cooperation between the IrOxand ZnO support also promoted its high reactivity. The selectivity of this catalyticN-methylation was controllable between dimethylation and monomethylation by carefully tuning the catalyst loading and reaction solvent. Specifically, neat methanol with high catalyst loading (2 mol% Ir) favored the formation ofN,N-dimethylated amine, while the mesitylene/methanol mixture with low catalyst loading (0.5 mol% Ir) was prone to producing mono-N-methylated amines. An environmentally benign continuous flow system with a recycled mode was also developed for the efficient production ofN-methylated amines. With optimal flow rates and amine concentrations, a variety ofN-methylamines were produced with good to excellent yields in this Ir/ZnO-based flow system, providing a starting point for the clean and efficient production ofN-methylamines with this cost-effective chemical process.

Oxidation of primary alcohols to methyl esters by hydrogen transfer

The oxidation of alcohols in the presence of methanol has been achieved using a ruthenium catalyst with crotononitrile as the hydrogen acceptor. The Royal Society of Chemistry.

Nickel-catalyzed direct electrochemical cross-coupling between aryl halides and activated alkyl halides

The electrochemical reduction of a mixture of aryl halides and activated alkyl halides in DMF in the presence of catalytic amount of NiBr2bipy leads to cross-coupling products in good to high yields. The method applies to the synthesis of α-aryl ketones, α-aryl esters, and allylated compounds from readily available organic halides. Optimization of the process has been obtained by slowly adding the most reactive organic halide (usually the activated alkyl halide) during the electrolysis which is best conducted at 70 °C when aryl bromides are involved.