6772-68-5

Basic information

• Product Name: 2-phenyl-1,4-dihydroisoquinolin-3(2H)-one
• Synonyms: 2-phenyl-1,4-dihydroisoquinolin-3(2H)-one
• CAS NO: 6772-68-5
• Molecular Weight: 223.274
• Mol File: 6772-68-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1,4-dihydroisoquinolin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1,4-dihydroisoquinolin-3(2H)-one(6772-68-5)
• EPA Substance Registry System: 2-phenyl-1,4-dihydroisoquinolin-3(2H)-one(6772-68-5)

Safety Data

• Hazardous Substances Data: 6772-68-5(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 10602-08-1 2-ethynylbenzyl alcohol 
• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 63969-83-5 2-formylphenylacetic acid methyl ester 
• 4385-35-7 isochroman-3-one 

Relevant articles and documents

Synthetic approaches to N- and 4-substituted 1,4-dihydro-3(2H)-isoquinolinone derivatives

Reaction of methyl-2-(2-formylphenyl)acetate with primary amines in a reductive amination/cyclisation process resulted in N-substituted 1,4-dihydro-3(2H)-isoquinolinones. With H2NCH2R sodium borohyride is a suitable reductant (11 examples), but H2NCHR1R2 required a transfer hydrogenation using ammonium formate catalysed by palladium on carbon (9 examples). 4-Substituted-1,4-dihydro-3(2H)-isoquinolinones were synthesised by deprotonation (n-butyllithium) and addition of R3CH2Br (12 examples with R3 = alkyl, Ar, CH[dbnd]CH2, C[tbnd]CH). Modest diastereoselectivity was achieved with 1,4-dihydro-3(2H)-isoquinolinones derived from H2NCHMeR2 [R2 = (η5-C5H4)Co(η4-C4Ph4) - max. dr = 1.9 : 1], but use of H2NCHMeFc (Fc = ferrocenyl) provided a new method of 1,4-dihydro-3(2H)-isoquinolinone N-deprotection with formic acid.

Synthetic approaches to 2-substituted 1-oxo- and 3-oxotetrahydroisoquinolines

2-Substituted homophthalimides 2a-c were reduced regioselectively with sodium borohydride to carbinol-lactam intermediates 3a-c, which were dehydrated, followed by hydrogenation, to give 1-oxotetrahydroisoquinolines or 3,4-dihydroisoquinolin-1(2H)ones 5a-c. The isomeric 3-oxo-tetrahydroisoquinolines or 1,4-dihydroisoquinolin-3(2H)-ones 8a-i were obtained in satisfactory yields via heating 3-isochromanone (6) with the corresponding amines 7a-i in the presence of aluminum chloride.