6775-40-2

Basic information

• Product Name: 5-PHENYL-1H-IMIDAZOL-2-AMINE
• Synonyms: 5-PHENYL-1H-IMIDAZOL-2-AMINE;1H-IMidazol-2-aMine, 4-phenyl-;5-Phenyl-1H-iMidazol-2-ylaMine;2-aMino-1H-4(5)-phenyliMidazole;4-phenyl-1H-imidazol-2-amine;4-Phenylimidazole-2-amine;4-Phenyl-1H-imidazol-2-ylamine
• CAS NO: 6775-40-2
• Molecular Formula: C₉H₉N₃
• Molecular Weight: 159.19
• Mol File: 6775-40-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 245 °C(Solv: ethanol (64-17-5))
• Boiling Point: 421.3±38.0 °C(Predicted)
• Appearance: /
• Density: 1.238±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.75±0.10(Predicted)
• CAS DataBase Reference: 5-PHENYL-1H-IMIDAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-1H-IMIDAZOL-2-AMINE(6775-40-2)
• EPA Substance Registry System: 5-PHENYL-1H-IMIDAZOL-2-AMINE(6775-40-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 6775-40-2(Hazardous Substances Data)

Usage

General Description

5-PHENYL-1H-IMIDAZOL-2-AMINE is a chemical compound with the molecular formula C9H9N3, and it belongs to the class of imidazole derivatives. It is a heterocyclic aromatic amine with a phenyl group attached to the second position of the imidazole ring. 5-PHENYL-1H-IMIDAZOL-2-AMINE is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds due to its unique structure and reactivity. It has been studied for its potential pharmacological properties, particularly in the development of novel drugs for the treatment of various diseases. Overall, 5-PHENYL-1H-IMIDAZOL-2-AMINE has potential applications in medicinal chemistry and drug discovery research.

Upstream product

• 15764-47-3 2-phenylimidazo(1,2-a)pyrimidine 
• 70-11-1 α-bromoacetophenone 
• 160041-64-5 N-<4(5)-Phenyl-1H-imidazol-2-yl>acetamide 
• 5699-40-1 monoacetylguanidine 
• 5699-40-1 acetylguanidine 

Downstream Products

• 76507-31-8 2-amino-5-bromo-4-phenylimidazole 
• 1245236-87-6 C₂₁H₁₇Cl₂N₃O₂ 
• 1345732-12-8 (E)-N-(4-phenyl-1H-imidazol-2-yl)cinnamamide 
• 1345732-21-9 4'-phenyl-N-(4-phenyl-1H-imidazol-2-yl)-1'H-pyrrole-3'-carboxamide 
• 1345732-30-0 4',5'-dihydro-4'-phenyl-N-(4-phenyl-1H-imidazol-2-yl)-1'H-pyrazole-3'-carboxamide 
• 1345732-39-9 4'-phenyl-N-(4-phenyl-1H-imidazol-2-yl)-1'H-pyrazole-3'-carboxamide 
• 1590443-72-3 4-(4-phenyl-1H-imidazol-2-yl)thiomorpholine-3,5-dione 
• 1590443-81-4 1,1-dioxo-4-(4-phenyl-1H-imidazol-2-yl)thiomorpholine-3,5-dione 
• 1616983-94-8 3'-(4-phenyl-1H-imidazol-2-ylamino)-5'-phenyl-4',5'-dihydropyrazole-1'-carbothioamide 
• 1616984-03-2 3'-(4-phenyl-1H-imidazol-2-ylamino)-5'-phenyl-1'H-pyrazole-1'-carbothioamide 
• 1616984-12-3 5'-phenyl-N-(4-phenyl-1H-imidazol-2-yl)-1'-(4-phenylthiazol-2-yl)-1'H-pyrazol-3'-amine 

Relevant articles and documents

Molecular properties prediction, synthesis, and antimicrobial activity of bis(azolyl)sulfonamidoacetamides

A library of bis(azolyl)sulfonamidoacetamides was prepared by the reaction of azolylsulfonylamines with azolylchloroacetamides in the presence of pyridine/4-(dimethylamino)pyridine (DMAP) under ultrasonication. The reaction proceeded well with DMAP, resulting in a higher yield of the products. The antimicrobial activity of the compounds indicated that N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl)amino}-2-oxoethyl)sulfamoyl]-4-phenylthiazol-2-yl}benzamide (22a), N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl]amino}-2-oxoethyl)sulfamoyl]-4-(4-chlorophenyl)thiazol-2-yl}benzamide (22c), and N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl]amino}-2-oxoethyl)sulfamoyl]-4-(4-chloro-phenyl)-1H-imidazol-2-yl}benzamide (24c) exhibited a low minimal inhibitory concentration (MIC) against Bacillus subtilis, equal to the standard drug, chloramphenicol. Compounds 22c and 24c also showed low MICs against Aspergillus niger, equal to the standard drug, ketoconazole. The molecular properties of the synthesized molecules were studied to identify druglikeness properties of the target compounds. On the basis of molecular properties prediction, 19a, 19b, 20b, 20c, 21a–c, 22b, 22c, and 23a–c can be treated as drug candidates.

Synthesis of carboxamide and sulfonyl carboxamide linked heterocycles under green conditions

Direct coupling of heteroaldehydes with heteroaryl amines / sulfonylamines is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines.

Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis

Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments are needed to combat emergence of drug resistance. Inosine 5′-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de novo synthesis of guanine nucleotid