677728-92-6 Usage
Description
2-Fluoropyridine-5-carboxaldehyde is an organic compound that features a fluorine atom at the 2nd position and a formyl group at the 5th position on a pyridine ring. It is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2-Fluoropyridine-5-carboxaldehyde is used as a key intermediate in the synthetic preparation of biheteroaryl arylamines. These compounds act as selective inhibitors of phosphoinositol 3-kinases (PI3K), which are crucial in the development and progression of various cancers. The selective inhibition of PI3K over mTOR makes these biheteroaryl arylamines potential antitumor agents, offering new therapeutic options for cancer treatment.
Additionally, 2-Fluoropyridine-5-carboxaldehyde can be utilized in the development of other bioactive molecules targeting different pathways and receptors, further expanding its applications in the pharmaceutical industry. Its unique fluorinated structure and reactivity make it a valuable building block for the design and synthesis of novel drugs with improved potency, selectivity, and pharmacokinetic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 677728-92-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,7,7,2 and 8 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 677728-92:
(8*6)+(7*7)+(6*7)+(5*7)+(4*2)+(3*8)+(2*9)+(1*2)=226
226 % 10 = 6
So 677728-92-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4FNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
677728-92-6Relevant articles and documents
Lewis basicity modulation of N-heterocycles: A key for successful cross-metathesis
Lafaye, Kevin,Nicolas, Lionel,Gurinot, Amandine,Reymond, Sbastien,Cossy, Janine
supporting information, p. 4972 - 4975 (2015/01/08)
Cross-metathesis involving N-heteroaromatic olefinic derivatives is disclosed. The introduction of an appropriate substituent on the heteroaromatic ring decreases the Lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.
TRPA1 ANTAGONISTS
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Page/Page column 28; 30, (2009/09/04)
Compounds of formula (I), wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
