67824-64-0Relevant articles and documents
Iron(III) catalyzed halo-functionalization of alkynes
Catano, Bryant,Lee, John,Kim, Claudia,Farrell, David,Petersen, Jeffrey L.,Xing, Yalan
supporting information, p. 4124 - 4127 (2015/08/03)
Abstract Aromatic and aliphatic alkynes can be halo-functionalized to α,α-dihalodimethyl ketals catalyzed by FeCl3 in excellent yields. MeOH is used as a nucleophilic solvent and N-halosuccinimide as the halogen source for this efficient transformation. The resulting α,α-dibromodimethyl ketals can be converted to the corresponding α,α-dibromoketones by treatment with 8% FeCl3 in silica gel.