679794-03-7

Basic information

• Product Name: 1-PHENYLSULFONYL-6-BROMOINDOLE
• Synonyms: 1-PHENYLSULFONYL-6-BROMOINDOLE;6-Bromo-1-(phenylsulfonyl)-1H-indole
• CAS NO: 679794-03-7
• Molecular Formula: C₁₄H₁₀BrNO₂S
• Molecular Weight: 336.2
• EINECS: 604-604-1
• Mol File: 679794-03-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 100-101 °C(Solv: methanol (67-56-1))
• Boiling Point: 498°C at 760 mmHg
• Flash Point: 255°C
• Appearance: /
• Density: 1.55g/cm³
• Vapor Pressure: 4.73E-10mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-PHENYLSULFONYL-6-BROMOINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYLSULFONYL-6-BROMOINDOLE(679794-03-7)
• EPA Substance Registry System: 1-PHENYLSULFONYL-6-BROMOINDOLE(679794-03-7)

Safety Data

• Hazardous Substances Data: 679794-03-7(Hazardous Substances Data)

Usage

General Description

1-Phenylsulfonyl-6-bromoindole is an organic compound with the molecular formula C14H10BrNO2S. It is a derivative of indole, and it is commonly used in organic synthesis and pharmaceutical research. This chemical compound is known for its diverse range of biological activities, including anti-inflammatory, anti-cancer, and antiviral properties. It has been studied for its potential use in developing new drugs for the treatment of various diseases, such as cancer and viral infections. Additionally, it is used as a building block in the synthesis of complex organic molecules due to its reactivity and versatility in organic chemistry.

InChI:InChI=1/C14H10BrNO2S/c15-12-7-6-11-8-9-16(14(11)10-12)19(17,18)13-4-2-1-3-5-13/h1-10H

Upstream product

• 52415-29-9 6-bromo-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 119-32-4 4-Methyl-3-nitroanilin 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 496-15-1 1-indoline 
• 78508-22-2 β-dimethylamino-2-nitrostyrene 
• 120-72-9 indole 

Downstream Products

• 1026346-82-6 4-(1-benzenesulfonyl-1H-indol-6-yl)-2-methyl-but-3-en-2-ol 
• 881406-31-1 6-bromo-1-phenylsulfonyl-1H-indole-3-sulfonyl chloride 
• 23158-16-9 6-(3-methylbut-2-en-1-yl)-1H-indole 
• 106851-31-4 6-phenyl-1H-indole 
• 1373438-69-7 (E)-5-bromo-N'-(1-(6-bromo-1H-indol-2-yl)ethylidene)-2-hydroxybenzohydrazide 
• 1572178-43-8 (E)-6-bromo-2-(2-(5-bromo-1-(phenylsulfonyl)-1H-indol-2-yl)vinyl)-1-(phenulsulfonyl)-1H-indole 
• 1572177-85-5 6-bromo-2-iodo-1-(phenylsulfonyl)-1H-indole 
• 1572178-41-6 C₃₃H₂₆BrNO₂PS⁽¹⁺⁾*Br^(1-) 
• 1572178-40-5 C₁₅H₁₁Br₂NO₂S 
• 1572178-39-2 (6-bromo-1-(phenylsulfonyl)-1H-indol-2-yl)methanol 

Relevant articles and documents

Concerning the preparation of 6-bromotryptamine

Most of the previous syntheses of the marine natural product 6-bromotryptamine have almost certainly led to partial debromination resulting in an impure product containing tryptamine. We show that loss of bromine occurs when lithium aluminum hydride is employed as a reducing agent in the final reaction step leading to 6-bromotryptamine. Reductive-debromination is also likely to intrude during some of the syntheses of 6-bromoindole, the typical precursor to 6-bromotryptamine. None of the seven described syntheses of 6-bromotryptamine that involve a reduction sequence from 6-bromoindole have reported elemental analyses as a measure of purity.

Construction of Oxepino[3,2-b]indoles via [4+3] Annulation of 2-Ylideneoxindoles with Crotonate-Derived Sulfur Ylides

A [4+3] annulation of 2-ylideneoxindoles with crotonate-derived sulfur ylides has been developed. A series of oxepino[3,2-b]indoles were prepared in moderate to excellent yields (62-93%) under mild conditions. Moreover, the synthetic oxepino[3,2-b] indoles can be further transformed into more complex cyclopropa[5,6]oxepino[3,2-b]indoles via a [2+1] cyclopropanation. In addition, the synthetic compounds show certain antiproliferative activity against K562 and MCF-7 cells, and its IC50 values for these two kinds of tumor cells up to 5.40±0.88 μM and 18.41±0.50 μM, respectively. (Figure presented.).

Highly diastereoselective synthesis of cyclopropane-fused spiro-pseudoindoxyl derivatives through [2 + 1] annulation of 2-ylideneoxindoles and sulfonium bromides

Compared with the intensively studied C3 spirooxindoles, limited reliable approaches are reported for synthesizing structurally analogous C2-spiropseudoindoxyl derivatives. Here, we developed an efficient method for highly diastereoselective synthesis of