68-42-8

Basic information

• Product Name: TETRAHYDROCORTICOSTERONE
• Synonyms: 5BETA-PREGNANE-3A,11BETA,21-TRIOL-20-ONE;5-BETA-PREGNANE-3-ALPHA,11-BETA,21-TRIOL-20-ONE;5-BETA-PREGNAN-3-ALPHA, 11-BETA, 21-TRIOL-20-ONE;3-ALPHA,11-BETA,21-TRIHYDROXY-5-BETA-PREGNAN-20-ONE;(6R)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN 2HCL;TH 'B';THB;TETRAHYDRO COMPOUND 'B'
• CAS NO: 68-42-8
• Molecular Formula: C₂₁H₃₄O₄
• Molecular Weight: 350.49
• EINECS: 200-690-5
• Product Categories: Steroids
• Mol File: 68-42-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 144～147℃
• Boiling Point: 509.6°C at 760 mmHg
• Flash Point: 276.1°C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 1.62E-12mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 12.98±0.10(Predicted)
• CAS DataBase Reference: TETRAHYDROCORTICOSTERONE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDROCORTICOSTERONE(68-42-8)
• EPA Substance Registry System: TETRAHYDROCORTICOSTERONE(68-42-8)

Safety Data

• Hazardous Substances Data: 68-42-8(Hazardous Substances Data)

Usage

Description

Tetrahydrocorticosterone, also known as THE, is a urinary steroid metabolite derived from the metabolism of cortisol, an essential hormone produced by the adrenal glands. It plays a significant role in the regulation of various physiological processes in the body, including the immune response, blood pressure, and glucose metabolism. Due to its association with adrenal function, it has been identified as a potential biomarker for certain pathological conditions.

Uses

Used in Medical Diagnostics:
Tetrahydrocorticosterone is used as a diagnostic biomarker for assessing adrenal function. Its levels can help identify abnormalities in the adrenal glands, which may be indicative of various adrenal-related disorders.
Used in Osteoporosis Research:
In postmenopausal women, the decrease in Tetrahydrocorticosterone levels has been linked to osteoporosis, a condition characterized by weakened bones and an increased risk of fractures. As a result, it is used as a potential biomarker for identifying individuals at risk of developing osteoporosis and monitoring the effectiveness of treatment strategies.
Used in Endocrinology:
Tetrahydrocorticosterone is also used in the field of endocrinology to study the relationship between cortisol metabolism and adrenal function. Understanding the role of this metabolite can provide insights into the complex interplay between the adrenal glands and other endocrine systems, leading to better diagnostic and treatment options for adrenal-related conditions.

InChI:InChI=1/C21H34O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-17,19,22-24H,3-11H2,1-2H3/t12-,13-,14+,15+,16-,17+,19-,20+,21+/m1/s1

Upstream product

• 566-03-0 3α,21-dihydroxy-5β-pregnane-11,20-dione 
• 97465-44-6 20.20-Aethylendioxy-5β-pregnantriol-(5α.11β.21) 
• 2526-11-6 3α-hydroxy-21-acetoxy-5β-pregnanedione-(11.20) 

Relevant articles and documents

Synthesis of mono- and diglucosiduronates of metabolites of deoxycorticosterone and corticosterone and analysis by a new mass spectrometric technique

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