68034-75-3Relevant articles and documents
Structure-Guided Identification of DNMT3B Inhibitors
Newton, Ana S.,Faver, John C.,Micevic, Goran,Muthusamy, Viswanathan,Kudalkar, Shalley N.,Bertoletti, Nicole,Anderson, Karen S.,Bosenberg, Marcus W.,Jorgensen, William L.
, p. 971 - 976 (2020)
Methyltransferase 3 beta (DNMT3B) inhibitors that interfere with cancer growth are emerging possibilities for treatment of melanoma. Herein we identify small molecule inhibitors of DNMT3B starting from a homology model based on a DNMT3A crystal structure.
PYRROLE DERIVATIVE
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Page 93, (2010/02/06)
A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein R1 means substituted alkenyl, etc.; R2 means substituted benzoyl, etc.; and R3 to R5 each means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.
Protein-tyrosine phosphatase inhibitors and uses thereof
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Page 21, (2010/02/09)
The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.