681035-98-3Relevant articles and documents
Unprecedented iron-catalyzed ester hydrogenation. Mild, selective, and efficient hydrogenation of trifluoroacetic esters to alcohols catalyzed by an iron pincer complex
Zell, Thomas,Ben-David, Yehoshoa,Milstein, David
supporting information, p. 4685 - 4689 (2014/05/20)
The synthetically important, environmentally benign hydrogenation of esters to alcohols has been accomplished in recent years only with precious-metal-based catalysts. Here we present the first iron-catalyzed hydrogenation of esters to the corresponding alcohols, proceeding selectively and efficiently in the presence of an iron pincer catalyst under remarkably mild conditions. The replacement of precious-metal catalysts by an iron complex was accomplished for the synthetically important, environmentally benign hydrogenation of esters to alcohols under mild conditions. The iron pincer complex (see scheme) selectively and efficiently catalyzes the hydrogenation of trifluoroacetates under remarkably mild conditions (5-25 bar and 40 °C).
Trifluoromethylated Vinylic and Aromatic Compounds from α-(Trifluoromethyl)allyl Alcohols
Radix-Large, Sylvie,Kucharski, Stephanie,Langlois, Bernard R.
, p. 456 - 465 (2007/10/03)
α-(Trifluoromethyl)allyl alcohols, easily available from α,β-unsaturated carbonyl compounds, are readily converted into γ-(trifluoromethyl)allyl thioethers, benzyl ethers, trifluoroacetates, and azides. A phenyl substituent at the γ-position to the hydroxyl function enhances their reactivity and the ease of SN2′ or SN1′ substitutions, whereas a phenyl ring at the α-position allows the BF3-mediated synthesis of (trifluoromethyl)indenes. 4-Alkyl-4-methoxy-1-(trifluoromethyl)cyclohexa-2,5- dienols, readily available from 4-alkylphenols, are easily converted to 4-alkyl(trifluoromethyl)benzenes bearing a nucleophilic substituent (MeO, Cl) either on the ring or the benzylic position.
