68266-50-2

Basic information

• Product Name: 2-<4-(cyclopentylmethyl)phenyl>propionic acid
• Synonyms: 2-<4-(cyclopentylmethyl)phenyl>propionic acid
• CAS NO: 68266-50-2
• Molecular Weight: 232.323
• Mol File: 68266-50-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-<4-(cyclopentylmethyl)phenyl>propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<4-(cyclopentylmethyl)phenyl>propionic acid(68266-50-2)
• EPA Substance Registry System: 2-<4-(cyclopentylmethyl)phenyl>propionic acid(68266-50-2)

Safety Data

• Hazardous Substances Data: 68266-50-2(Hazardous Substances Data)

Upstream product

• 43153-03-3 2-(4-chloromethylphenyl)-propionic ethyl ester 
• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 
• 33240-34-5 cyclopentylmagnesium bromide 
• 68767-14-6 loxoprofen 

Relevant articles and documents

Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2

Chemokines CXCL8 and CXCL1 play a key role in the recruitment of neutrophils at the site of inflammation. CXCL8 binds two membrane receptors, CXCR1 and CXCR2, whereas CXCL1 is a selective agonist for CXCR2. In the past decade, the physiopathological role of CXCL8 and CXCL1 has been investigated. A novel class of small molecular weight allosteric CXCR1 inhibitors was identified, and reparixin, the first drug candidate, is currently under clinical investigation in the prevention of ischemia/reperfusion injury in organ transplantation. Reparixin binding mode to CXCR1 has been studied and used for a computer-assisted design program of dual allosteric CXCR1 and CXCR2 inhibitors. In this paper, the results of modeling-driven SAR studies for the identification of potent dual inhibitors are discussed, and three new compounds (56, 67, and 79) sharing a common triflate moiety have been selected as potential leads with optimized pharmacokinetic characteristics.

Novel phenylacetic acid derivatives

Phenylacetic acid derivatives of the formula STR1 wherein n is an integer of 2 to 5; STR2 R1 is hydrogen, halogen, trifluoromethyl, nitro or amino; R2 and R3 each independently is hydrogen or lower alkyl; or together form an ethylene group; X1 represents two hydrogen atoms or an oxo group; and Y1 is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl or carboxyl; and for derivatives wherein Y is carboxyl, salts thereof with physiologically compatible bases, esters thereof from physiologically acceptable alcohols and amides thereof from physiologically acceptable amines have valuable pharmacological activity, e.g., as antiinflammatory agents.