68280-05-7

Basic information

• Product Name: 4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)-
• Synonyms: 4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)-;N-(2,6-dimethylphenyl)-4-Pyridinecarboxamide;N-(2,6-dimethylphenyl)pyridine-4-carboxamide;isonicotinic acid-(2,6-dimethyl-anilide)
• CAS NO: 68280-05-7
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226
• Mol File: 68280-05-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)-(68280-05-7)
• EPA Substance Registry System: 4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)-(68280-05-7)

Safety Data

• Hazardous Substances Data: 68280-05-7(Hazardous Substances Data)

Usage

General Description

4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)- is a chemical compound with the molecular formula C14H14N2O. It is a derivative of pyridine and is commonly used as a building block in the synthesis of pharmaceutical and agrochemical products. 4-PyridinecarboxaMide, N-(2,6-diMethylphenyl)- is a white to off-white solid with a melting point of around 128-130°C. It is also known for its role as an intermediate in the production of various active pharmaceutical ingredients and has applications in the manufacturing of antibiotics, antifungal agents, and other medicinal products. Additionally, it is utilized in the chemical industry for the synthesis of various organic compounds.

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 87-62-7 2,6-dimethylaniline 
• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 1453-82-3 isonicotinamide 

Downstream Products

• 111589-43-6 4-(2,6-dimethyl-phenylcarbamoyl)-1-methyl-pyridinium; iodide 
• 109403-19-2 piperidine-4-formyl-(2,6-dimethyl)aniline 
• 97740-33-5 1-ethyl-piperidine-4-carboxylic acid-(2,6-dimethyl-anilide) 
• 1220349-02-9 C₂₁H₂₀N₂O 

Relevant articles and documents

Synthesis method of piperidine carboxylic acid amide drug intermediate N-(2,6-dimethyl benzene)-4-pyridine carboxamide

A synthesis method of piperidine carboxylic acid amide drug intermediate N-(2,6-dimethyl benzene)-4-pyridine carboxamide comprises steps as follows: 1.1 mol of pyridine-4-formamide and 600-620 ml of nitromethane are added to a reaction container provided with a stirrer and a thermometer, the stirring speed is controlled to range from 130 rpm to 160 rpm, 0.4-0.42 mol of cuprous bromide is added in batches, the temperature of the solution is increased to 100-105 DEG C, the solution reacts for 2-3 h, filtration is performed, a filtrate is added to the reaction container again, 1.1-1.3 mol of 2,6-xylidine is added dropwise, the stirring speed is kept for 5-6 h after addition, the temperature of the solution is decreased to 15-18 DEG C, solids separate out, filtration is performed, the solids are washed with ethyl acetate, N-(2,6-dimethyl benzene)-4-pyridine carboxamide bromate is obtained and dissolved in 1,100 ml of a potassium nitrate solution, decolorization is performed with a molecular sieve, a sodium sulfite solution is added to adjust the pH to range from 9 to 10, the temperature of the solution is decreased to 3-5 DEG C, solids separate out, filtration is performed, the solids are washed with a salt solution, dehydrated with a dehydrating agent and recrystallized in chlorobenzene, and the N-(2,6-dimethyl benzene)-4-pyridine carboxamide is obtained.