68313-46-2

Basic information

• Product Name: 4-AMINOQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: 4-AMINOQUINOLINE-3-CARBOXYLIC ACID;3-Quinolinecarboxylicacid,4-amino-(9CI);4-amino-3-quinolinecarboxylic acid(SALTDATA: FREE)
• CAS NO: 68313-46-2
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.18272
• Product Categories: AMINOACID
• Mol File: 68313-46-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 409.8 ºC at 760 mmHg
• Flash Point: 201.6 ºC
• Appearance: /
• Density: 1.43 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.745
• CAS DataBase Reference: 4-AMINOQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOQUINOLINE-3-CARBOXYLIC ACID(68313-46-2)
• EPA Substance Registry System: 4-AMINOQUINOLINE-3-CARBOXYLIC ACID(68313-46-2)

Safety Data

• Hazardous Substances Data: 68313-46-2(Hazardous Substances Data)

Usage

General Description

4-Aminoquinoline-3-carboxylic acid is a chemical compound with the molecular formula C10H8N2O2. It is a derivative of quinoline and contains an amino group and a carboxylic acid group. 4-AMINOQUINOLINE-3-CARBOXYLIC ACID is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It also has biological activity and has been studied for its potential use in treating malaria and other diseases. 4-Aminoquinoline-3-carboxylic acid has been shown to exhibit antimalarial and antitumor properties, making it a valuable compound in medicinal chemistry research.

InChI:InChI=1/C10H8N2O2/c11-9-6-3-1-2-4-8(6)12-5-7(9)10(13)14/h1-5H,(H2,11,12)(H,13,14)

Upstream product

• 75353-48-9 acide carbamoyl-4 quinoleinecarboxylique-3 
• 93074-72-7 ethyl 4-aminoquinoline-3-carboxylate 

Downstream Products

• 75353-53-6 amino-4 quinoleinecarboxylate de methyle-3 

Relevant articles and documents

Synthesis and in vitro biological evaluation of new polyamine conjugates as potential anticancer drugs

The synthesis of new polyamine derivatives containing dimeric quinoline (3a-c), cinnoline (4a-c) and phthalimide (7a-c and 8a-c) moieties is described. Three different polyamines: (1,4-bis(3-aminopropyl)piperazine (a), 4,9-dioxa-1,12-dodecanediamine (b), 3,3′-diamino-N-methyldipropylamine (c) were used as linkers. The new compounds were obtained according to known procedures. Their biological activity was assessed in vitro in a highly aggressive melanoma cell line A375. Polyamine diimides containing phthalimide moieties demonstrated no inhibitory activities against melanoma cells. Quinoline diamides were more efficient than cinnoline ones. Mainly cytostatic activity exerted as altered cell cycle profiles was observed at the concentrations causing about 50% reduction of adherent cell proliferation. Based on their structure as well as their biological activity, we assume that some of the newly synthesized compounds may act as DNA bisintercalators. This study might be useful for further designing and developing anticancer drugs with potent activities.

Sur les orthoamino formyl quinoleines, nouveaux synthons heterocycliques

Les quatre orthoamino formyl quinoleines substituees sur le cycle pyridinique ont ete synthetisees par oxydation des amino hydroxymethyl quinoleines correspondantes.Parmi toutes les methodes envisagees, seule cette derniere a permis la preparation de l'amino-3 formyl-2 quinoleine, compose relativement peu stable.Ces nouveaux composes bifonctionnels derives de la qunoleine constituent des synthons particulierement interessants pour l'elaboration de certains heterocycles.