68347-92-2

Basic information

• Product Name: 6-(4'-chlorophenyl)imidazo<2,1-b>thiazole-3-acetic acid
• Synonyms: 6-(4'-chlorophenyl)imidazo<2,1-b>thiazole-3-acetic acid
• CAS NO: 68347-92-2
• Molecular Weight: 292.746
• Mol File: 68347-92-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-(4'-chlorophenyl)imidazo<2,1-b>thiazole-3-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4'-chlorophenyl)imidazo<2,1-b>thiazole-3-acetic acid(68347-92-2)
• EPA Substance Registry System: 6-(4'-chlorophenyl)imidazo<2,1-b>thiazole-3-acetic acid(68347-92-2)

Safety Data

• Hazardous Substances Data: 68347-92-2(Hazardous Substances Data)

Upstream product

• 752931-73-0 {3-[2-(4-chloro-phenyl)-2-oxo-ethyl]-2-imino-2,3-dihydro-thiazol-4-yl}-acetic acid ethyl ester 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 53266-94-7 ethyl 2-amino-1,3-thiazol-4-acetate 
• 68347-85-3 ethyl 6-(4'-chlorophenyl)imidazo<2,1-b>thiazole-3-acetate 

Downstream Products

• 1388831-93-3 2-(6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(6-fluoropyridin-3-yl)acetamide 
• 1388832-01-6 2-(6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(6-(4-(4-fluorobenzyl)piperazin-1-yl)pyridin-3-yl)acetamide 
• 1388831-99-9 2-(6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(6-(4-(4-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)acetamide 
• 1388831-89-7 2-(6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(6-methoxypyridin-3-yl)acetamide 
• 1388831-92-2 2-(6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(6-chloropyridin-3-yl)acetamide 
• 1388831-97-7 2-(6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-acetamide 

Relevant articles and documents

Synthesis and cytotoxic activity of some novel N-pyridinyl-2-(6- phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives

A series of novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl) acetamide (5a), and tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. The results indicated that the compound 2-(6-(4-chlorophenyl)imidazo [2,1-b]thiazol-3-yl)-N-(6-(4-(4-methoxybenzyl) piperazin-1-yl)pyridin-3-yl)acetamide (5l), with slightly higher inhibition on VEGFR2 than 5a (5.72% and 3.76% inhibitory rate at 20 μM, respectively), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).