68426-09-5Relevant articles and documents
Total Asymmetric Synthesis of (+)-Paroxetine and (+)-Femoxetine
Szcze?niak, Piotr,Buda, Szymon,Lefevre, Laura,Staszewska-Krajewska, Olga,Mlynarski, Jacek
, p. 6973 - 6982 (2019/11/20)
Total, asymmetric synthesis of (+)-Paroxetine and (+)-Femoxetine, selective serotonin reuptake inhibitors, used for the treatment of depression, anxiety, and panic disorders is reported. The key step is organocatalytic Michael addition of aldehydes to trans-nitroalkenes realized in bath or continues flow. High efficiency and selectivity in the Michael addition was achieved by application of Wang resin-supported Hayashi–J?rgensen catalyst.
Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers
Liu, Yajun,Park, Se Kyung,Xiao, Yan,Chae, Junghyun
supporting information, p. 4747 - 4753 (2014/06/24)
A highly efficient copper-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper(ii) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good to excellent yields. In this newly developed protocol, aliphatic diols have multilateral functions as coupling reactants, ligands, and solvents. The resulting hydroxyalkyl aryl ethers were further readily converted into the corresponding phenols, presenting a valuable alternative way to phenols from aryl bromides. Furthermore, it was demonstrated that they are useful intermediates for more advanced molecules such as benzofurans and benzo-fused cyclic ethers. This journal is
The synthesis of some new hydrazone derivatives containing the benzothiazole moiety
Oezdemir, Ahmet,Turan-Zitouni, Guelhan,Kaplancikli, Zafer Asim,Altintop, Mehlika Dilek
, p. 141 - 146 (2012/06/18)
Hydrazones are an important class of compounds found in many synthetic products. Due to their importance in synthetic chemistry, the present article reports the synthesis of a new series of ten compounds based on the coupling of 2-oxo-3(2H)-benzothiazoleacetic acid, hydrazide and 2-thioxo-3(2H)- -benzothiazoleacetic acid, hydrazide with different aldehydes. The structures of the synthesized compounds were confirmed by elemental analyses, IR, 1H- -NMR, 13C-NMR and FAB+-MS spectral data. Copyright 2012 (CC) SCS.