6843-36-3

Basic information

• Product Name: 2-(MethylcarbaMoyl)benzoic acid
• Synonyms: 2-(MethylcarbaMoyl)benzoic acid
• CAS NO: 6843-36-3
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17266
• EINECS: -0
• Mol File: 6843-36-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 407.146°C at 760 mmHg
• Flash Point: 200.035°C
• Appearance: /
• Density: 1.259g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 2-(MethylcarbaMoyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(MethylcarbaMoyl)benzoic acid(6843-36-3)
• EPA Substance Registry System: 2-(MethylcarbaMoyl)benzoic acid(6843-36-3)

Safety Data

• Hazardous Substances Data: 6843-36-3(Hazardous Substances Data)

Usage

Type of compound

Derivative of benzoic acid.

Functional group

Contains a methylcarbamoyl group, classifying it as a carbamate.

Usage

Serves as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Biological activity

Identified as a potential inhibitor of cell proliferation.

Research interest

Being studied for its anticancer properties.

Pest control application

Found to have insecticidal activity.

Antifungal properties

Exhibits antifungal activity.

Versatility

Potential applications in various industries due to its multiple beneficial properties.

InChI:InChI=1/C9H9NO3/c1-10-8(11)6-4-2-3-5-7(6)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13)

Upstream product

• 85-44-9 phthalic anhydride 
• 74-89-5 methylamine 
• 550-44-7 N-methylphthalimide 
• 7732-18-5 water 
• 136918-14-4 phthalimide 

Downstream Products

• 550-44-7 N-methylphthalimide 

Relevant articles and documents

Base-controlled product switch in the ruthenium-catalyzed protodecarbonylation of phthalimides: A mechanistic study

The whole reaction mechanism of the ruthenium-catalyzed protodecarbonylation of N-substituted phthalimides into secondary amides was unravelled by a combined experimental and theoretical study. The chemoselectivity of the reaction, which is catalyzed by para-cymene coordinated Ru(ii) species all over the catalytic cycle, is exclusively controlled by the unique roles of the bases. Meanwhile, in the presence of K2CO3 or KOH at high temperatures, the same product (benzamide) is mainly formed, whereas at low temperatures, KOH led to an unexpected side-product (phthalamic acid) and no reactivity was observed with K2CO3. The non-covalent interactions between the potassium cations and the different carbonyl groups in the molecules are key to providing a thermodynamically favourable pathway with energetically accessible transition states. The unexpected formation of carbon dioxide (CO2) in the course of the reaction originates from the phthalimide substrate and the base K2CO3 in two different elementary steps, respectively.

Compounds and methods for inducing chondrogenesis

The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.

A convenient method of N-methylphthalimide synthesis

We suggest a convenient method to obtain N-methylphthalimide with a high yield in the reaction of phthalic anhydride with aqueous methylamine.