686781-16-8

Basic information

• Product Name: {(S)-1-[(S)-2-((S)-3-Isobutyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-2-ylmethyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
• Synonyms: {(S)-1-[(S)-2-((S)-3-Isobutyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-2-ylmethyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester
• CAS NO: 686781-16-8
• Molecular Weight: 494.656
• Mol File: 686781-16-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(S)-1-[(S)-2-((S)-3-Isobutyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-2-ylmethyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(S)-1-[(S)-2-((S)-3-Isobutyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-2-ylmethyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester(686781-16-8)
• EPA Substance Registry System: {(S)-1-[(S)-2-((S)-3-Isobutyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidin-2-ylmethyl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid benzyl ester(686781-16-8)

Safety Data

• Hazardous Substances Data: 686781-16-8(Hazardous Substances Data)

Upstream product

• 686781-13-5 C₃₀H₄₈N₄O₉S 
• 686781-14-6 C₂₉H₄₈N₄O₈S 
• 56439-35-1 Cbz-L-Val-L-propinol 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 91650-00-9 Cbz-L-Val-L-propinal 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 686781-15-7 (S)-5-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-4-isobutyl-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidine-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design, synthesis, and in vitro evaluation of inhibitors of human leukocyte elastase based on a functionalized cyclic sulfamide scaffold

The design of novel functionalized templates capable of binding to the active site of serine proteases could potentially lead to the development of potent and highly selective non-covalent inhibitors of these enzymes. Using the elastase-turkey ovomucoid inhibitor complex and insights gained from earlier work based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold (I), a surrogate cyclosulfamide scaffold (II) was used for the first time in the design of reversible inhibitors of human leukocyte elastase. Compounds 7 and 8 were found to be micromolar reversible inhibitors of the enzyme.