68691-66-7Relevant articles and documents
Role of the C(6)-hydroxy group in bicyclomycin: Synthesis, structure, and chemical, biochemical, and biological properties
Santillán Jr., Alejandro,Zhang, Xiangdong,Hardesty, Jon,Widger, William R.,Kohn, Harold
, p. 1185 - 1194 (1998)
Bicyclomycin (1) is a commercial antibiotic whose primary site of action in Escherichia coli is the transcription termination factor rho. A recent structure-activity relationship study of 1 showed that replacing the C(6)- hydroxy group with alkoxy and thi