68692-77-3

Basic information

• Product Name: (1-phenylcyclohexane)methanol
• Synonyms: (1-phenylcyclohexane)methanol
• CAS NO: 68692-77-3
• Molecular Formula: C₁₃H₁₈O
• Molecular Weight: 192.2973
• EINECS: 272-081-2
• Mol File: 68692-77-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 54-56 °C(Solv: hexane (110-54-3))
• Boiling Point: 305.1°C at 760 mmHg
• Flash Point: 128.1°C
• Appearance: /
• Density: 1.014g/cm³
• Vapor Pressure: 0.000368mmHg at 25°C
• Refractive Index: 1.533
• PKA: 15.05±0.10(Predicted)
• CAS DataBase Reference: (1-phenylcyclohexane)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-phenylcyclohexane)methanol(68692-77-3)
• EPA Substance Registry System: (1-phenylcyclohexane)methanol(68692-77-3)

Safety Data

• Hazardous Substances Data: 68692-77-3(Hazardous Substances Data)

Usage

Description

(1-phenylcyclohexane)methanol is an organic compound that features a phenyl group connected to a cyclohexane ring, with a methanol functional group also attached. It is a versatile building block in organic chemistry, known for its aromatic properties and wide range of applications.

Uses

Used in Industrial and Laboratory Settings:
(1-phenylcyclohexane)methanol is used as a solvent for various chemical processes and reactions due to its ability to dissolve a broad range of substances.
Used in Pharmaceutical Synthesis:
(1-phenylcyclohexane)methanol is used as a precursor in the synthesis of various pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Fragrance and Flavor Production:
(1-phenylcyclohexane)methanol is used as a key component in the production of fragrances and flavors, capitalizing on its aromatic properties to create desirable scents and tastes.
Used in Organic Chemistry Research:
(1-phenylcyclohexane)methanol is used as a valuable building block in organic chemistry research, enabling the exploration of new chemical reactions and the creation of novel compounds.
It is important to handle (1-phenylcyclohexane)methanol with care, as it can be toxic and may cause irritation if it comes into contact with the skin or eyes.

InChI:InChI=1/C13H18O/c14-11-13(9-5-2-6-10-13)12-7-3-1-4-8-12/h1,3-4,7-8,14H,2,5-6,9-11H2

Upstream product

• 1135-67-7 1-phenyl-cyclohexanecarboxylic acid 
• 17380-78-8 methyl 1-phenyl-1-cyclohexanecarboxylate 
• 2201-23-2 1-phenyl-1-cyclohexanecarbonitrile 
• 111-24-0 1,5-dibromo-pentane 
• 22612-69-7 1-phenylcyclohexane-1-carbaldehyde 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 136089-16-2 O-<2-<2-(diethylamino)ethoxy>ethyl>-1-phenyl-1-cyclohexanemethanol 
• 17380-78-8 methyl 1-phenyl-1-cyclohexanecarboxylate 
• 1135-67-7 1-phenyl-cyclohexanecarboxylic acid 
• 32294-72-7 (1-phenylcyclohexyl)acetonitrile 
• 500340-80-7 methanesulfonic acid 1-phenylcyclohexylmethyl ester 
• 1616922-11-2 9-hydroxy-2-isopropyl-6-(1-phenylcyclohexylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-37-8 2-(1-phenylcyclohexyl)acetamidine hydrochloride 
• 1616924-38-9 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester 
• 1616924-39-0 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid 
• 1616924-40-3 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide 
• 1616924-41-4 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide 
• 1616924-42-5 9-benzyloxy-2-isopropyl-6-(1-phenylcyclohexylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 22612-69-7 1-phenylcyclohexane-1-carbaldehyde 

Relevant articles and documents

Selective Aerobic Oxidation of Primary Alcohols to Aldehydes

The 2-azaadamantane- N -oxyl (AZADO)- and 9-azanoradamantane- N -oxyl (nor-AZADO)-catalyzed selective oxidation of primary alcohols to the corresponding aldehydes is described. The use of tert -butyl nitrite as the co-catalyst enables efficient aerobic oxidation in MeCN instead of previously reported AcOH; this is important for the selectivity of the reaction. The addition of a solution of saturated aqueous NaHCO 3 after the completion of the reaction was effective to suppress the overoxidation of the product to the corresponding carboxylic acid during the workup.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents

A series of analogues based on the anticonvulsant carbetapentane (1, 2-[2- (diethylamino)ethoxy]ethyl 1-phenyl-1-cyclopentylcarboxylate) was prepared as potential novel anticonvulsant drugs. Structure-activity relationships of analogues in which the ester function and cyclopentane moieties were modified have been investigated by evaluating their ability to prevent seizures in the rat maximal electroshock test. These compounds (11, ED50 = 16 μmol/kg; 12, ED50 = 86 μmol/kg, and 23, ED50 = 173 μmol/kg) were effective anticonvulsants. Compound 11, an alkyl ether derivative of 1, was more potent than the parent compound (ED50 = 48 μmol/kg) and also showed a 2-fold increase in potency compared to that of the prototypic anticonvulsant drug diphenylhydantoin.