68737-65-5 Usage
Description
(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine, also known as (R,R)-(-)-N,N′-Dimethyl-1,2-cyclohexanediamine, is a N,N′-dimethylated derivative of enantiopure 1,2-diaminocyclohexane. It is characterized by its white to light yellow crystal powder appearance and can be formed during the hydrolysis of specific chemical compounds.
Uses
Used in Pharmaceutical Synthesis:
(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine is used as a ligand in the preparation of 4H-benzo[f]imidazo[1,4]diazepin-6-one through a multi-component Ullmann coupling reaction. This application is significant for the development of new pharmaceutical compounds with potential therapeutic properties.
Used in the Synthesis of Tricyclic γ-secretase Modulators:
In the field of medicinal chemistry, (1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine serves as a key component in one of the synthetic steps for the preparation of tricyclic γ-secretase modulators. These modulators are important for the treatment of various neurodegenerative diseases, such as Alzheimer's disease.
Used in Catalyst Preparation for Polymerization:
(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine is used to prepare chiral fluorous diamino-diol proligand, which is then utilized in the synthesis of zirconium metal complexes. These complexes are applicable as catalysts in the polymerization of 1-hexene, a process that is crucial in the production of various types of polymers and plastics in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 68737-65-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,7,3 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 68737-65:
(7*6)+(6*8)+(5*7)+(4*3)+(3*7)+(2*6)+(1*5)=175
175 % 10 = 5
So 68737-65-5 is a valid CAS Registry Number.
68737-65-5Relevant articles and documents
Synthesis of chiral salan ligands with bulky substituents and their application in Cu-catalyzed asymmetric Henry reaction
He, Jianghao,Mu, Ying,Wang, Zhou
, (2020/10/09)
Several new chiral N,N’-dimethylated salan ligands with bulky substituents were synthesized and their in-situ generated Cu(II) complexes were evaluated in the asymmetric Henry reaction. Substituents on the aryloxide moieties of these ligands were found to
Method for synthesizing trans-cyclohexanedimethanamine
-
, (2017/08/28)
The invention discloses a method for synthesizing trans-cyclohexanedimethanamine, comprising steps of reacting cyclohexene oxide and methylamine aqueous solution under the catalysis of boric acid, and then adding sulfuric acid, dewatering to form an ester, ring-closing under alkaline conditions, adding methylamine aqueous solution and boric acid for hermetic reaction, and distilling to obtain trans-cyclohexanedimethanamine. The synthetic process is simple to perform, provides facilitated isolation and purification and high yield and product purity, and is suitable for batch production.
Novel chiral bisformamide-promoted asymmetric allylation of benzaldehyde with allyltrichlorosilane
Ishimaru, Kaori,Ono, Kaori,Tanimura, Yuya,Kojima, Takakazu
scheme or table, p. 3627 - 3634 (2011/10/09)
Novel chiral bisformamides have been prepared from (R,R)-1,2- cyclohexanediamine and utilized as Lewis bases in the asymmetric allylation of benzaldehyde with allyltrichlorosilane. The reaction in the presence of Lewis base 1i gave an 83:17 enantiomeric r
