68867-18-5 Usage
Description
2-METHYL-1,3-BENZOTHIAZOL-6-OL is an organic compound with the molecular formula C7H7NO2S. It is a heterocyclic compound featuring a benzene ring fused to a thiazole ring, with a methyl group at the 2nd position and a hydroxyl group at the 6th position. This chemical structure endows it with unique properties and reactivity, making it a valuable building block in the synthesis of various pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Industry:
2-METHYL-1,3-BENZOTHIAZOL-6-OL is used as a reactant for the preparation of G protein-biased D2 dopamine receptor partial agonists. These agonists are important in the development of drugs targeting neurological and psychiatric disorders, such as schizophrenia and Parkinson's disease. 2-METHYL-1,3-BENZOTHIAZOL-6-OL's unique structure allows for the fine-tuning of the agonist's activity, potentially leading to more effective and safer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 68867-18-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,8,6 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 68867-18:
(7*6)+(6*8)+(5*8)+(4*6)+(3*7)+(2*1)+(1*8)=185
185 % 10 = 5
So 68867-18-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NOS/c1-5-9-7-3-2-6(10)4-8(7)11-5/h2-4,10H,1H3
68867-18-5Relevant articles and documents
Photochemical Ring Contraction of Dihydro-1,4-benzothiazines
Costantini, Claudio,Testa, Gennaro,Crescenzi, Orlando,d'Ischia, Marco
, p. 3365 - 3366 (1994)
The pheomelanin precursors 1a and the related dihydro-1,4-benzothiazines 1b-f undergo ring contraction upon irradiation with pyrex-filtered UV light to give 2-methylbenzothiazoles 2a-f in good yields.
Processes and intermediates for the preparation of N4-phenyl-quinazoline-4-amine derivatives
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Page/Page column 51-52, (2009/09/05)
This invention provides compounds of Formula (I), wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
High-yielding cleavage of (aryloxy)acetates
Spurg, Anke,Waldvogel, Siegfried R.
, p. 337 - 342 (2008/09/18)
A reliable and high-yielding one-pot sequence for the removal of O-carboxymethyl moieties from phenols is presented. When diethylphosphoryl azide is employed as the azide transfer reagent in the Curtius rearrangement and glycerol in the subsequent hydrolytic workup, the protocol can be reliably applied to a very broad scope of substrates. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.