68913-85-9

Basic information

• Product Name: 2,3,4-TRIMETHOXYPHENYLACETONITRILE
• Synonyms: 2,3,4-TRIMETHOXYPHENYLACETONITRILE
• CAS NO: 68913-85-9
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Mol File: 68913-85-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 29-31°C
• Boiling Point: 135°C 1mm
• Flash Point: 126.9 °C
• Appearance: /
• Density: 1.104 g/cm³
• Vapor Pressure: 0.00041mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: 2,3,4-TRIMETHOXYPHENYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-TRIMETHOXYPHENYLACETONITRILE(68913-85-9)
• EPA Substance Registry System: 2,3,4-TRIMETHOXYPHENYLACETONITRILE(68913-85-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 68913-85-9(Hazardous Substances Data)

Usage

General Description

2,3,4-TRIMETHOXYPHENYLACETONITRILE is a chemical compound that belongs to the class of acetonitriles. It consists of a phenyl ring with three methoxy groups attached at the 2nd, 3rd, and 4th positions, and a nitrile group attached to the acetic acid side chain. 2,3,4-TRIMETHOXYPHENYLACETONITRILE is commonly used in organic synthesis and medicinal chemistry as an intermediate in the production of various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and properties make it a valuable building block for the synthesis of diverse biologically active molecules. Additionally, 2,3,4-TRIMETHOXYPHENYLACETONITRILE may also have potential applications in materials science and other fields due to its versatile reactivity and functional groups.

InChI:InChI=1/C11H13NO3/c1-13-9-5-4-8(6-7-12)10(14-2)11(9)15-3/h4-5H,6H2,1-3H3

Upstream product

• 68913-84-8 2-[(Z)-Hydroxyimino]-3-(2,3,4-trimethoxy-phenyl)-propionic acid 
• 71989-96-3 2,3,4-trimethoxybenzylalcohol 
• 1133-49-9 2,3,4-trimethoxybenzyl chloride 
• 773837-37-9 sodium cyanide 
• 80054-01-9 2,3,4-trimethoxybenzyl bromide 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 89155-11-3 2-Amino-3-(2,3,4-trimethoxy-phenyl)-benzo[4,5]thieno[3,2-b]pyran-4-one 
• 116753-61-8 3-Methyl-2-(2,3,4-trimethoxy-phenyl)-butyronitrile 
• 83485-59-0 2-Amino-3-(2,3,4-trimethoxy-phenyl)-thiochromen-4-one 
• 103525-48-0 2-Isopropyl-5-{[3-(2-methoxy-phenoxy)-propyl]-methyl-amino}-2-(2,3,4-trimethoxy-phenyl)-pentanenitrile 
• 106318-35-8 2-Isopropyl-5-[3-(2-methoxy-phenoxy)-propylamino]-2-(2,3,4-trimethoxy-phenyl)-pentanenitrile 
• 22480-91-7 (2,3,4-trimethoxy-phenyl)-acetic acid 

Relevant articles and documents

TUBULIN BINDING AGENTS

The invention provides combretastatin A-4 like compounds that are modified to have enhanced tubulin binding activity and in some embodiments the ability to promote accumulation in the vasculature undergoing angiogenesis (homing activity). The compounds are based on the combretastatin A-4 skeletal structure having a tubulin-binding pharmacophore comprising two fused rings (A and B rings) in which the B ring is substituted with (a) an aromatic ring structure (C ring) and (b) a second substituent/functional group that comes off the B ring. The aromatic ring structure is typically a six membered ring phenolic or aniline structure, or may also be a fused ring structure such as a substituted or unsubstituted naphthalene. The second substituent on the B ring may for example be a substituent which has been found to provide enhanced tubulin binding activity (for example a carbonyl group), or may be a substituent that facilitates functionalisation of the B ring (for example an hydroxyl or amine group), or it may be a binding agent for a target that is preferentially expressed on vasculature undergoing angiogenesis, and not expressed on quiescent vasculature.

Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation

Compound of general formula I STR1 wherein A is a benzo or thieno group; R1 is (C4-6)cycloalkyl, (C4-6)cycloalkyl-(C1-5)alkyl or STR2 R2, m, R3, R4, R and u are defined as in the specification, and pharmaceutical preparations containing this compound and the new pharmaceutical uses thereof.