68938-62-5

Basic information

• Product Name: 2-hydroxy-3-phenoxypropyl p-toluenesulphonate
• Synonyms: 2-hydroxy-3-phenoxypropyl p-toluenesulphonate;4-Methylbenzenesulfonic acid 2-hydroxy-3-phenoxypropyl ester
• CAS NO: 68938-62-5
• Molecular Formula: C₁₆H₁₈O₅S
• Molecular Weight: 322.37612
• EINECS: 273-134-2
• Mol File: 68938-62-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 518.8°C at 760 mmHg
• Flash Point: 267.6°C
• Appearance: /
• Density: 1.273g/cm³
• Vapor Pressure: 1.37E-11mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-hydroxy-3-phenoxypropyl p-toluenesulphonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-phenoxypropyl p-toluenesulphonate(68938-62-5)
• EPA Substance Registry System: 2-hydroxy-3-phenoxypropyl p-toluenesulphonate(68938-62-5)

Safety Data

• Hazardous Substances Data: 68938-62-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H18O5S/c1-13-7-9-16(10-8-13)22(18,19)21-12-14(17)11-20-15-5-3-2-4-6-15/h2-10,14,17H,11-12H2,1H3

Upstream product

• 538-43-2 3-phenoxy-1,2-propanediol 
• 122-60-1 Phenyl glycidyl ether 
• 546-68-9 titanium(IV)isopropoxide 
• 3087-39-6 titanium(IV) tert-butoxide 
• 5593-70-4 titanium (IV) butoxide 
• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 127840-19-1 Acetic acid (R)-1-phenoxymethyl-2-(toluene-4-sulfonyloxy)-ethyl ester 
• 187982-10-1 C₂₁H₂₆O₆S 

Relevant articles and documents

Regioselective Sulfonylation/Acylation of Carbohydrates Catalyzed by FeCl3 Combined with Benzoyltrifluoroacetone and Its Mechanism Study

A catalytic amount of FeCl3 combined with benzoyl trifluoroacetone (Hbtfa) (FeCl3/Hbtfa = 1/2) was used to catalyze sulfonylation/acylation of diols and polyols using diisopropylethylamine (DIPEA) or potassium carbonate (K2CO3) as a base. The catalytic system exhibited high catalytic activity, leading to excellent isolated yields of sulfonylation/acylation products with high regioselectivities. Mechanism studies indicated that FeCl3 initially formed [Fe(btfa)3] (btfa = benzoyl trifluoroacetonate) with twice the amount of Hbtfa under basic conditions in the solvent acetonitrile at room temperature. Then, Fe(btfa)3 and two hydroxyl groups of the substrates formed a five- or six-membered ring intermediate in the presence of the base. The subsequent reaction between the cyclic intermediate and a sulfonylation reagent led to the selective sulfonylation of the substrate. All key intermediates were captured in the high-resolution mass spectrometry assay, therefore demonstrating this mechanism for the first time.

Naphthyloxy acetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient

The naphthyloxyacetic acid derivatives of the formula (I) wherein A is H, -(alkylene)COOR1, -(alkylene)CONR2R3, -(alkylene)OH, -(alkylene)tetrazole, -(alkylene)CN; E is single bond or alkylene; G is —S—, —SO—, —SO2—, —O— or —NR4—; L is alkylene, —(CH2)m—CH═CH—(CH2)n— or —(CH2)x—CH(OH)—(CH2)y—; M is phenyl, phenyl(thio, oxy, amino), diphenylmethyl, diphenylmethyl(thio, oxy, amino), and pharmaceutical composition comprising them as an active ingradient. The compounds of the formula (I) can combine PGE2receptor and exhibit the activity to antagonize or agonize for PGE2receptor. Therefore, they are useful as anti-hyperlipemia, for the prevention of abortion, for analgesics, as antidiarrheals, sleep inducer, diuretic, anti-diabetes, abortient, cathartics, antiulcer, anti-gastritis or antihypertensive etc.

A CHEMOENZYMATIC ACCESS TO OPTICALLY ACTIVE 1,2-EPOXIDES

Lipase-catalyzed transacylation in organic media was employed to produce optically active α-hydroxy tosylate which could be readily converted to the corresponding 1,2-epoxides with high optical purity.