690-95-9

Basic information

• Product Name: 4,4,4-TRIFLUOROBUTYRONITRILE
• Synonyms: 4-CYANO-1,1,1-TRIFLUOROPROPANE;4,4,4-TRIFLUOROBUTYRONITRILE;4,4,4-Trifluorobutanenitrile 97%;4,4,4-Trifluorobutyronitrile97%;4,4,4-Trifluorobutanenitrile;3,3,3-Trifluoroprop-1-yl cyanide, 4,4,4-Trifluorobutyronitrile
• CAS NO: 690-95-9
• Molecular Formula: C4H4F3N
• Molecular Weight: 123.08
• Mol File: 690-95-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 139-140°C
• Flash Point: 13.1 °C
• Appearance: /
• Density: 1,21 g/cm3
• Vapor Pressure: 40.6mmHg at 25°C
• Refractive Index: 1.324
• CAS DataBase Reference: 4,4,4-TRIFLUOROBUTYRONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-TRIFLUOROBUTYRONITRILE(690-95-9)
• EPA Substance Registry System: 4,4,4-TRIFLUOROBUTYRONITRILE(690-95-9)

Safety Data

• Hazard Codes: Xi,T,F
• Statements: 20/21/22-36/37/38
• Safety Statements: 23-26-36/37/39
• RIDADR: 3276
• HazardClass: TOXIC, FLAMMABLE
• Hazardous Substances Data: 690-95-9(Hazardous Substances Data)

Usage

General Description

4,4,4-Trifluorobutyronitrile is a chemical compound with a molecular formula of C4H4F3N. 4,4,4-TRIFLUOROBUTYRONITRILE belongs to the family of nitriles, which are organic compounds that contain a -C≡N functional group. Trifluorobutyronitrile is hydrophobic, indicating that it doesn't mix well with water, and the presence of three fluorine atoms can contribute to its overall stability and reactivity. Its specific applications can vary widely, although compounds of this nature often find use in the field of synthetic chemistry as precursors or building blocks for more complex molecules. Detailed information about its physiological and environmental impacts are scarcely available, so safe handling and use are advised until more is understood about its safety profile.

InChI:InChI=1/C4H4F3N/c5-4(6,7)2-1-3-8/h1-2H2

Upstream product

• 107-13-1 acrylonitrile 
• 76-05-1 trifluoroacetic acid 
• 406-87-1 4,4,4-trifluorobutanal 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 84476-96-0 trans-4,4,4-trifluorocrotononitrile 
• 461-34-7 4,4,4-trifluorobutyroamide 

Downstream Products

• 2794-32-3 4,4,4-trifluoro-butyramidine hydrochloride 

Relevant articles and documents

SUBSTITUTED PYRAZOLE COMPOUNDS AS TOLL RECEPTOR INHIBITORS

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Nanopalladium-catalyzed conjugate reduction of Michael acceptors-application in flow

A continuous-flow approach towards the selective nanopalladium-catalyzed hydrogenation of the olefinic bond in various Michael acceptors, which could lead to a greener and more sustainable process, has been developed. The nanopalladium is supported on aminofunctionalized mesocellular foam. Both aromatic and aliphatic substrates, covering a variation of functional groups such as acids, aldehydes, esters, ketones, and nitriles were selectively hydrogenated in high to excellent yields using two different flow-devices (H-Cube and Vapourtec). The catalyst was able to hydrogenate cinnamaldehyde continuously for 24 h (in total hydrogenating 19 g cinnanmaldehyde using 70 mg of catalyst in the H-cube) without showing any significant decrease in activity or selectivity. Furthermore, the metal leaching of the catalyst was found to be very low (ppb amounts) in the two flow devices.

PYRROLIDINONE GLUCOKINASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.