69049-06-5 Usage
Description
Different sources of media describe the Description of 69049-06-5 differently. You can refer to the following data:
1. Alfentanil is a narcotic analgesic with a
more rapid onset and shorter duration of
action than its structural relative fentanyl. The primary utility of alfentanil is in
surgical analgesia/anesthesia, especially for cardiac compromised patients and in
procedures of short duration.
2. Alfentanil (hydrochloride) (Item No. 19292) is an analytical reference standard characterized as an opioid. Alfentanil is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemical Properties
Tan Solid
Originator
Jansseu (Belgium)
Uses
An opioid analgesic receptor agonist for pain treatment. Tetrazole derivative of Fentanyl. Analgesic (narcotic).
Controlled substance (opiate)
Manufacturing Process
A mixture of 22 parts of 1-ethyl-1,4-dihydro-5H-tetrazol-5-one, 45 parts of 1-
bromo-2-chloroethane, 26 parts of sodium carbonate, 0.3 part of potassium
iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed
overnight with water-separator. The reaction mixture is cooled, water is added
and the layers are separated. The aqueous phase is extracted three times with dichloromethane. The combined organic phases are dried, filtered and
evaporated. The residue is purified by column-chromatography over silica gel
using trichloromethane as eluent. The pure fractions are collected and the
eluent is evaporated, yielding 28.4 parts (80%) of 1-(2-chloroethyl)-4-ethyl-
1,4-dihydro-5H-tetrazol-5-one as a residue.
A mixture of 1.8 parts of 1-(2-chloroethyl)-4-ethyl-1,4-dihydro-5H-tetrazol-5-
one, 3.45 parts of N-[4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide,
5 parts of sodium carbonate, 0.2 part of potassium iodide
and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with
water-separator. The reaction mixture is poured onto water and the layers are
separated. The organic phase is dried, filtered and evaporated. The residue is
purified by column-chromatography over silicagel using a mixture of
trichloromethane and methanol (97:3 by volume) as eluent. The pure
fractions are collected and the eluent is evaporated. The residue is converted
into the hydrochloride salt in 2-propanone. The salt is filtered off and
crystallized from 2-propanone, yielding 1.5 parts (33.3%) of N-[1-[2-(4-ethyl-
4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide
monohydrochloride monohydrate; melting point 140.8°C.
Brand name
Alfenta (Akorn);RAPIFEN.
Therapeutic Function
Narcotic analgesic
Check Digit Verification of cas no
The CAS Registry Mumber 69049-06-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,0,4 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 69049-06:
(7*6)+(6*9)+(5*0)+(4*4)+(3*9)+(2*0)+(1*6)=145
145 % 10 = 5
So 69049-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H32N6O3.ClH/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26;/h6-10H,4-5,11-17H2,1-3H3;1H
69049-06-5Relevant articles and documents
Configuration and conformation of alfentanil hydrochloride. Conformational study by NMR and theoretical calculations
Jaime, Carlos,Virgili, Albert,Portillo, Susana,Caparros, Antoni,Burusco, Kepa K.
, p. 440 - 447 (2014)
The configurational and conformational structure of alfentanil hydrochloride (1) was studied by nuclear magnetic resonance and theoretical calculations. Compound 1 is best described by equilibrium between two stereoisomeric piperidinium rings with the N-s
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