690961-82-1

Basic information

• Product Name: N-(4-acetylphenyl)-3-fluorobenzenesulfonamide
• Synonyms: N-(4-acetylphenyl)-3-fluorobenzenesulfonamide
• CAS NO: 690961-82-1
• Molecular Weight: 293.319
• Mol File: 690961-82-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-acetylphenyl)-3-fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-acetylphenyl)-3-fluorobenzenesulfonamide(690961-82-1)
• EPA Substance Registry System: N-(4-acetylphenyl)-3-fluorobenzenesulfonamide(690961-82-1)

Safety Data

• Hazardous Substances Data: 690961-82-1(Hazardous Substances Data)

Upstream product

• 701-27-9 3-fluorobenzene-1-sulfonyl chloride 
• 99-92-3 p-aminobenzophenone 

Relevant articles and documents

Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators

Pyruvate kinase M2 isoform (PKM2) is a crucial protein responsible for aerobic glycolysis of cancer cells. Activation of PKM2 may alter aberrant metabolism in cancer cells. In this study, we discovered a 4-hydroxy-thiazolidine-2-thione compound 2 as a novel PKM2 activator from a random screening of an in-house compound library. Then a series of novel 4-hydroxy-thiazolidine-2-thione derivatives were designed and synthesized for screening as potent PKM2 activators. Among these, some compounds showed higher PKM2 activation activity than lead compound 2 and also exhibited significant anti-proliferative activities on human cancer cell lines at nanomolar concentration. The compound 5w was identified as the most potent antitumor agent, which showed excellent anti-proliferative effects with IC50 values from 0.46 μM to 0.81 μM against H1299, HCT116, Hela and PC3 cell lines. 5w also showed less cytotoxicity in non-tumor cell line HELF compared with cancer cells. In addition, Preliminary pharmacological studies revealed that 5w arrests the cell cycle at the G2/M phase in HCT116 cell line. The best PKM2 activation by compound 5t was rationalized through docking studies.

α-Mercaptoketone based histone deacetylase inhibitors

In an effort to discover novel non-hydroxamic acid histone deacetylase (HDAC) inhibitors, a novel α-mercaptoketone was identified in a high-throughput screen. Lead optimization of the screening hit, led to a number of potent HDAC inhibitors. In particular, α-mercaptoketone 19y (KD5150) exhibited nanomolar in vitro activity and inhibition of tumor growth in vivo.