691006-33-4Relevant articles and documents
A Tuneable Ge-based Linker that Enables Application-led Solid Phase Synthesis Optimisation - Towards a Robust Iterative Synthesis of Oligothiophenes
Spivey, Alan C.,Turner, David J.,Turner, Michael L.,Yeates, Stephen
, p. 111 - 115 (2004)
A convenient synthesis of a new dichlorogermanium-based linker-precursor for solid phase synthesis is described that allows facile introduction of a range of 'spectator' substituents (R) onto germanium. Variation of these R groups allows modulation of the stability of the key germanium-carbon bond between the linker and the aryl library. The tuning process is exemplified by application to the optimisation of a linker for the iterative solid-phase synthesis (SPS) of oligothiophenes.