69159-49-5

Basic information

• Product Name: 1-Benzhydryl-N-methyl-3-azetidinamine
• Synonyms: 1-Benzhydryl-N-methyl-3-azetidinamine;1-benzhydryl-N-methylazetidin-3-amine;1-(diphenylMethyl)-N-Methylazetidin-3-aMine;1-DiphenylMethyl-(3-Methy...;1-(Diphenylmethyl)-3-(methylamino)azetidine;N-(1-Benzhydrylazetidin-3-yl)-N-methylamine
• CAS NO: 69159-49-5
• Molecular Formula: C₁₇H₂₀N₂
• Molecular Weight: 252.36
• Mol File: 69159-49-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 349℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.10
• Vapor Pressure: 4.84E-05mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-Benzhydryl-N-methyl-3-azetidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzhydryl-N-methyl-3-azetidinamine(69159-49-5)
• EPA Substance Registry System: 1-Benzhydryl-N-methyl-3-azetidinamine(69159-49-5)

Safety Data

• Hazardous Substances Data: 69159-49-5(Hazardous Substances Data)

Usage

General Description

1-Benzhydryl-N-methyl-3-azetidinamine, also known as desloratadine, is an antihistamine drug used to relieve symptoms of allergic conditions such as hay fever, hives, and allergic skin rashes. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms, and is typically taken orally. Desloratadine is an active metabolite of loratadine and has a longer duration of action and higher efficacy compared to its parent compound. It is considered a second-generation antihistamine and is generally well-tolerated with minimal sedative effects, making it a popular choice for the treatment of allergic conditions.

InChI:InChI=1/C17H20N2/c1-18-16-12-19(13-16)17(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16-18H,12-13H2,1H3

Upstream product

• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 74-89-5 methylamine 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 

Downstream Products

• 133891-77-7 3-(methylamino)azetidine dihydrochloride 
• 147293-68-3 1-(diphenylmethyl)-3-azetidine 
• 854038-91-8 N-(1-benzhydrylazetidin-3-yl)-N-methylcarbamic acid tert-butyl ester 
• 935668-13-6 N-(1-benzhydryl-3-azetidino)-N-methylacetamide 

Relevant articles and documents

Macrocyclic Spiro Pyrimidine Derivatives

Macrocyclic spiro pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.

AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention relates to novel amino pyrimidine compounds of formula (I) for the modulation of the histamine H4 receptor and the treatment or prevention of conditions mediated by the histamine H4 receptor. The invention also relates to the preparation of such compounds.

Quantitative structure-activity relationships of antibacterial agents, 7-heterocyclic amine substituted 1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acids

Quantitative structure-activity relationships (QSAR) of various 7-(3-substituted-azetidin-1-yl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro -4-oxoquinoline-3-carboxylic acids, 14-25, were studied to clarify the structural requirements for 3-substituted azetidi