693225-89-7Relevant articles and documents
Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists
Sato, Nagaaki,Shibata, Takunobu,Jitsuoka, Makoto,Ohno, Toshiyuki,Takahashi, Toshiyuki,Hirohashi, Tomoko,Kanno, Tetsuya,Iwaasa, Hisashi,Kanatani, Akio,Fukami, Takehiro
, p. 1761 - 1764 (2007/10/03)
A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described.