6938-33-6Relevant articles and documents
Preparation method of (E)-3-(3-furyl) acrylic acid
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Paragraph 0084-0085, (2020/08/30)
The invention belongs to the technical field of medical intermediates, and provides a preparation method of a nalfurafine intermediate (E)-3-(3-furyl) acrylic acid. The method comprises the followingsteps: generating the nalfurafine intermediate (E)-3-(3-furyl) acrylic acid from a 3-substituted furan compound and an acrylate compound under the action of a catalyst; the method is mild in reactioncondition, simple and convenient to operate and high in reaction yield, and the obtained product is high in isomerization purity; a refining process and a waste liquid treatment process are avoided sothat the production cost is reduced, and the environmental protection pressure is reduced.