69408-81-7Relevant articles and documents
Real-Time Multi-Photon Tracking and Bioimaging of Glycosylated Theranostic Prodrugs upon Specific Enzyme Triggered Release
Calatrava-Pérez, Elena,Elmes, Robert B. P.,Gunnlaugsson, Thorfinnur,Lynch, Dylan M.,Marchetti, Luke A.,McManus, Gavin J.,Scanlan, Eoin M.,Williams, D. Clive
, (2021/12/09)
Real-time tracking of prodrug uptake, delivery and activation in vivo represents a major challenge for prodrug development. Herein, we demonstrate the use of novel glycosylated theranostics of the cancer pharmacophore Amonafide in highly-selective, enzyma
Hydrogen sulfide triggered molecular agent for imaging and cancer therapy
Ge, Chao,Di, Xiaojiao,Han, Siqi,Wang, Mengmeng,Qian, Xiaoting,Su, Zhi,Liu, Hong-Ke,Qian, Yong
supporting information, p. 1931 - 1934 (2021/03/02)
We developed an activatable molecular reagent, PNF, triggered by intracellular H2S in the lysosome to release the therapeutic drug amonafide, which can escape from the lysosome into the nucleus to induce autophagy of cancer cells. PNF exhibits potent inhibitory activity against cisplatin-resistant tumor cell lines.
Fluorescent probe for detecting tiredness level Preparation method and application thereof
-
Paragraph 0044; 0053-0055, (2021/09/08)
The invention discloses a fluorescence probe for detecting the level of hypoxia, a preparation method and application thereof, and can realize specific response Na. 2 S2 O4 The fluorescence probe is used for detecting the tiredness level, and the structure is as follows. The probe comprises a nitrogen-nitrogen double bond, which can be broken down in a hypoxic environment to cause fluorescence recovery of the compound. The naphthalimide is introduced as a fluorophore, and has the characteristics of stable fluorescence and high fluorescence quantum efficiency. The fluorescent probe is simple and convenient to prepare, obvious in spectral change, good in specificity effect, small in cytotoxicity, good in imaging effect and good in specificity detection Na. 2 S2 O4 , The fluorophore precursor and the anti-tumor drug nitrogen mustard compound can be released under the hypoxic condition, the tumor cell growth can be inhibited while the hypoxia imaging is carried out, the diagnosis and treatment integrated function is achieved, and the application prospect is good.