69511-66-6Relevant articles and documents
Unexpected cyclization ofortho-nitrochalcones into 2-alkylideneindolin-3-ones
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, Nicolai A.,Aksenova, Daria S.,Arutiunov, Nikolai A.,Rubin, Michael
, p. 18440 - 18450 (2020/06/08)
An original, facile, and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles fromortho-nitrochalcones is described. The featured transformation is a triggered Michael addition of the cyanide anion to the chalcone followed by a cascade cyclization mechanistically related to the Baeyer-Drewson reaction.