6953-32-8

Basic information

• Product Name: (4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine
• CAS NO: 6953-32-8
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.2952
• Mol File: 6953-32-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 461.777°C at 760 mmHg
• Flash Point: 233.075°C
• Density: 1.231g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: (4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine(CAS DataBase Reference)
• NIST Chemistry Reference: (4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine(6953-32-8)
• EPA Substance Registry System: (4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine(6953-32-8)

Safety Data

• Hazardous Substances Data: 6953-32-8(Hazardous Substances Data)

Usage

Description

(4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine is a complex chemical compound characterized by its imine functional group and a chromen-4-imine moiety. It also includes a methoxyphenyl substituent and a hydroxyl group, which may contribute to its potential interactions with biological molecules. (4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine could possess pharmacological or physiological activity, warranting further investigation into its properties and possible applications.

Uses

Used in Pharmaceutical Industry:
(4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine is used as a potential pharmaceutical agent for its possible pharmacological activity. The presence of the imine group and the hydroxyl group may allow it to interact with biological targets, suggesting its use in the development of new drugs or therapeutic agents.
Used in Chemical Research:
In the field of chemical research, (4E)-N-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-imine serves as a subject of study for understanding the properties and reactivity of complex molecular structures. Its unique features may provide insights into new chemical reactions or mechanisms, contributing to the advancement of synthetic chemistry.

Upstream product

• 3327-24-0 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 3034-08-0 2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one 
• 34000-29-8 [E]-3-(p-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 

Downstream Products

• 4143-74-2 4'-methoxyflavone 
• 3034-08-0 2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one 
• 132594-11-7 3-acetoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 95731-61-6 Acetic acid 2-(4-methoxy-phenyl)-4-oxo-chroman-3-yl ester 
• 95319-67-8 N‐{[(4‐methylphenyl)sulfonyl]oxy}‐2‐(4‐methoxyphenyl)‐2,3‐dihydro‐4H‐chromen‐4‐imine 

Relevant articles and documents

Synthesis and hplc-ecd study of cytostatic condensed o,n-heterocycles obtained from 3-aminoflavanones

Racemic chiral O,N-heterocycles containing 2-arylchroman or 2-aryl-2H-chromene subunit condensed with morpholine, thiazole, or pyrrole moieties at the C-3-C-4 bond were synthesized with various substitution patterns of the aryl group by the cyclization of cis- or trans-3- aminoflavanone analogues. The 3-aminoflavanone precursors were obtained in a Neber rearrangement of oxime tosylates of flavanones, which provided the trans diastereomer as the major product and enabled the isolation of both the cis- and trans-diastereomers. The cis- and transaminoflavanones were utilized to prepare three diastereomers of 5-aryl-chromeno[4,3- b][1,4]oxazines. Antiproliferative activity of the condensed heterocycles and precursors was evaluated against A2780 and WM35 cancer cell lines. For a 3-(N-chloroacetylamino)-flavan-4-ol derivative, showing structural analogy with acyclic acid ceramidase inhibitors, 0.15 μM, 3.50 μM, and 6.06 μM IC50 values were measured against A2780, WM35, and HaCat cell lines, and apoptotic mechanism was confirmed. Low micromolar IC50 values down to 2.14 μM were identified for the thiazole- and pyrrole-condensed 2H-chromene derivatives. Enantiomers of the condensed heterocycles were separated by HPLC using chiral stationary phase, HPLC-ECD spectra were recorded and TDDFT-ECD calculations were performed to determine the absolute configuration and solution conformation. Characteristic ECD transitions of the separated enantiomers were correlated with the absolute configuration and effect of substitution pattern on the HPLC elution order was determined.

CHALCONE OXIMES. PART V. REACTION OF HYDROXYLAMINE WITH 4-SUBSTITUTED 2'-HYDROXYCHALCONES

The reactions of hydroxylamine with 4-substituted 2'-hydroxychalcones have been investigated.Formation of products of 1,2 addition and simultaneous 1,4 and 1,2 addition for R = -CH3, -Cl have been established.Products of 1,2 addition for R = -OCH3 and of