6953-83-9

Basic information

• Product Name: 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE
• Synonyms: 4-AMINO-3-CHLOROACETOPHENONE;1-(4-Amino-3-dimethylaminomethyl-phenyl)-ethanone
• CAS NO: 6953-83-9
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.61
• Product Categories: pharmacetical
• Mol File: 6953-83-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 324.6 °C at 760 mmHg
• Flash Point: 150.1 °C
• Appearance: /
• Density: 1.254 g/cm³
• Vapor Pressure: 0.000243mmHg at 25°C
• Refractive Index: 1.586
• PKA: 0.22±0.10(Predicted)
• CAS DataBase Reference: 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE(6953-83-9)
• EPA Substance Registry System: 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE(6953-83-9)

Safety Data

• Hazardous Substances Data: 6953-83-9(Hazardous Substances Data)

Usage

General Description

1-(4-amino-3-chloro-phenyl)-ethanone, also known as 4-Amino-3-chloroacetophenone, is a chemical compound with the molecular formula C8H8ClNO. It is a clear, colorless to pale yellow liquid and is commonly used as an intermediate in the synthesis of various pharmaceutical compounds. This chemical is also known to have potential applications in the field of organic synthesis and research. Its structure consists of a phenyl ring with an amino group and a chloro group attached to it, as well as an acetophenone moiety. 1-(4-amino-3-chloro-phenyl)-ethanone is known to be an important building block in the production of various drugs and pharmaceuticals.

InChI:InChI=1/C8H8ClNO/c1-5(11)6-2-3-8(10)7(9)4-6/h2-4H,10H2,1H3

Upstream product

• 54839-95-1 N-[2-chloro-4-acetyl-phenyl]-acetamide 
• 2642-63-9 3',4'-dichloroacetophenone 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 99-92-3 p-aminobenzophenone 
• 91238-44-7 N-chloro-p-acetylacetanilide 
• 2401-21-0 1,2-Dichloro-3-iodobenzene 
• 95-51-2 o-chloroaniline 

Downstream Products

• 116686-84-1 3'-chloro-4-nitroacetophenone 
• 116687-02-6 4'-amino-3'-phenoxyacetophenone 
• 116720-30-0 1-(4-Amino-3-o-tolyloxy-phenyl)-ethanone 
• 116687-10-6 4'-Amino-3'-(4-chlorophenoxy)acetophenone 
• 116687-22-0 4'-amino-3'-(3-chlorophenoxy)acetophenone 
• 116687-04-8 1-[4-Amino-3-(2-fluoro-phenoxy)-phenyl]-ethanone 
• 116687-08-2 4'-Amino-3'-(2-chlorophenoxy)acetophenone 
• 116687-29-7 1-[4-Amino-3-(2-bromo-phenoxy)-phenyl]-ethanone 
• 116687-24-2 2-(3-chloro-4-nitrophenyl)-2-methyl-1,3-dioxolane 
• 116687-01-5 4'-nitro-3'-phenoxyacetophenone 
• 116687-31-1 4'-Amino-3'-(2-methoxyphenoxy)acetophenone 
• 116687-43-5 4'-Amino-3'-(2,3-dichlorophenoxy)acetophenone 
• 116687-23-1 1-[4-Amino-3-(2,5-dichloro-phenoxy)-phenyl]-ethanone 
• 116687-27-5 4'-Amino-3'-(2,6-dichlorophenoxy)acetophenone 

Relevant articles and documents

Phenylethanolamine β receptor agonist synthetic method

The invention discloses a phenylethanolamine β receptor agonist synthetic method, comprises the following steps: S1: the 4 - amino acetophenone dissolved in an organic solvent, with the electrophilic reagent occurs on the benzene ring substituted halogenated reaction, generating [...] intermediate; [...] intermediates in organic solvent or in water, under the catalysis of the metal catalyst with the cyanide reagent undergo nucleophilic substitution reaction, generating phenyl ketone intermediate; S2: phenyl ketone intermediates in organic solvent, with the copper bromide generating carbonyl α bromo reaction to produce α - bromoacetophenone intermediates; S3: α - bromoacetophenone intermediates in organic solvent with tert-butyl amine or isopropylamine reaction intermediates acetophenone amines; S4: acetophenone amine intermediates in organic solvent, with the reduction hydrogenation reagent react to generate the phenylethanolamine β receptor agonists; synthetic method of this invention a simple and highly efficient and cheap and easy to obtain, atom utilization is high, the synthetic product chemical purity is greater than 99%, to meet the detection requirements of the food safety.

Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII

A series of benzenesulfonamide derivatives, bearing benzimidazole moieties, were designed and synthesized as inhibitors of carbonic anhydrases (CAs). Their binding affinities to recombinant human CA isozymes I, II, VII, XII and XIII were determined by the

Ecofriendly solvent free microwave enhanced thermal Fries rearrangement of anilides and phenyl ureas

A rapid, cleaner, cost effective and ecofriendly synthesis of exclusive para aminoaryl ketones and para aminoaryl amides in solvent free conditions using solid supports under microwave irradiation is achieved.