69555-16-4

Basic information

• Product Name: Alanine, N-(diphenylmethylene)-, ethyl ester
• CAS NO: 69555-16-4
• Molecular Formula: C18H19NO2
• Molecular Weight: 281.354
• Mol File: 69555-16-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Alanine, N-(diphenylmethylene)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Alanine, N-(diphenylmethylene)-, ethyl ester(69555-16-4)
• EPA Substance Registry System: Alanine, N-(diphenylmethylene)-, ethyl ester(69555-16-4)

Safety Data

• Hazardous Substances Data: 69555-16-4(Hazardous Substances Data)

Upstream product

• 1013-88-3 Benzophenone imine 
• 1115-59-9 (S)-alanine ethyl ester hydrochloride 
• 617-27-6 DL-alanine ethyl ester hydrochloride 
• 69555-14-2 ethyl N-diphenylmethylene glycine 
• 74-88-4 methyl iodide 

Downstream Products

• 195601-04-8 Ethyl 2-(2,2-dichloro-3,3-diphenylaziridin-1-yl)propanoate 
• 1202077-72-2 ethyl 2-(diphenylmethyleneamino)-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoate 
• 1202077-73-3 C₄₁H₃₆FN₃O₂S 
• 1360817-16-8 ethyl 2-(diphenylmethyleneamino)-4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-methylbutanoate 
• 1255216-05-7 C₂₅H₂₅NO₂ 
• 169390-29-8 DL-Ala(α-propionitrile)-OEt 

Relevant articles and documents

A convenient method for the enantiomeric separation of α-amino acid esters as benzophenone imine schiff base derivatives

A convenient liquid chromatographic method for the separation of α-amino acid esters as benzophenone Schiff base derivatives on coated chiral stationary phases (CSPs) (Chiralcel OD-H, Chiralcel OD, Chiralpak AD-H, Chiralpak AD, and Chiralpak AS) or covalently immobilized CSPs (Chiralpak IA, Chiralpak IB, and Chiralpak IC) derived from polysaccharide derivatives is described. Benzophenone imine derivatives of α-amino acid esters were readily prepared by stirring benzophenone imine and the hydrochloride salts of α-amino acid esters in 2-propanol. The chromatographic separations were conducted at a flow rate 1.0 mL/min and a detection wavelength of 254 nm; 0.5% 2-propanol/hexane (v/v) was used on CSPs. In general, the resolution of Chiralpak IC was superior to those of the other CSPs. In addition, the resolutions of other arylimine derivatives of α-amino acid esters and the effects of different mobile phases on the enantiomeric separation of α-amino acid esters as benzophenone imine derivatives on Chiralpak IC were investigated.

Palladium catalysed asymmetric alkylation of benzophenone Schiff base glycine esters in ionic liquids

Asymmetric alkyl substitution of various benzophenone Schiff base substrates under biphasic conditions proceeded using optically active Palladium(II) complexes. The corresponding products were obtained in high yields but with moderate enantiomeric excess (ee) . Addition of specific ionic liquids to the reaction medium enhanced reactivity and selectivity for phase transfer catalytic (PTC) glycine alkylation. It has been found that there is an anionic influence of the ionic liquids that modify the steric environment around the enolate ion. A computer-assisted molecular design of enantioselective phase-transfer catalysis with the palladium complex and the ionic liquid has been done. Indian Academy of Sciences.

Easy and efficient generation of reactive anions with free and supported ylides as neutral Bronsted bases

The tris(dimethylamino)-C-dimethylphosphorus ylide 5 and the tris(dimethylamino)phosphorus ylide C-bound to Merrifield's resin 6 are used as strong non-nucleophilic bases in N-alkylation reactions of β-amino phosphine oxides and α-amino acid derivatives,