69684-83-9

Basic information

• Product Name: 6-FLUORO-4-CHROMANONE HYDANTOIN
• Synonyms: 6-FLUORO-4-CHROMANONE HYDANTOIN;6-FLUOROCHROMAN-4-ONE HYDANTOIN;AKOS 91025;2,3-Dihydro-6-fluoro-2H',5H'-spiro[chromene-4,4'-imidazolidine]-2',5'-dione;6-Fluorospiro[chroman-4,4'-imidazolidine]-2',5'-dione
• CAS NO: 69684-83-9
• Molecular Formula: C₁₁H₉FN₂O₃
• Molecular Weight: 236.2
• Mol File: 69684-83-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: >240°C
• Appearance: /
• CAS DataBase Reference: 6-FLUORO-4-CHROMANONE HYDANTOIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-4-CHROMANONE HYDANTOIN(69684-83-9)
• EPA Substance Registry System: 6-FLUORO-4-CHROMANONE HYDANTOIN(69684-83-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36-37-38
• Safety Statements: 26
• Hazardous Substances Data: 69684-83-9(Hazardous Substances Data)

Usage

General Description

6-FLUORO-4-CHROMANONE HYDANTOIN is a chemical compound that is a derivative of both 4-chromanone and hydantoin. It is a heterocyclic compound with a fluorine atom attached to the 6th position of the chromanone ring. 6-FLUORO-4-CHROMANONE HYDANTOIN is of interest for its potential pharmacological properties, particularly as an anticonvulsant. It has been studied for its ability to modulate the activity of ion channels in the brain, which could make it useful in the treatment of epilepsy and other neurological disorders. The structure of 6-FLUORO-4-CHROMANONE HYDANTOIN makes it a valuable tool for medicinal chemistry research and drug development. More research is needed to fully understand its pharmacological effects and potential applications.

Upstream product

• 151-50-8 potassium cyanide 
• 66892-34-0 6-fluoro-4-chromanone 
• 371-41-5 4-Fluorophenol 
• 1579-78-8 3-(4-fluoro-phenoxy)propionic acid 
• 85169-02-4 3-(4-fluoro-phenoxy)propionitrile 
• 66892-47-5 6'-fluoro-spiro[imidazolidine-4,4'-thiochroman]-2,5-dione 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 79791-46-1 (S)-4-cyano-2,3-dihydro-6-fluoro-4-<(S)-(1-phenylethyl)amino>-4H-1-benzopyran 
• 590-28-3 potassium cyanate 
• 103834-11-3 (S)-4-amino-6-fluoro-chromane-4-carboxylic acid 
• 917-61-3 sodium isocyanate 
• 103197-16-6 methyl (4S)-amino-2,3-dihydro-6-fluoro-4H-1-benzopyran-4-carboxylate 
• 79791-48-3 (S)-2,3-dihydro-6-fluoro-3'-<(S)-1-phenylethyl>spiro<4H-1-benzopyran-4,4'-imidazolidine>-2',5'-dione 
• 158554-70-2 C₁₅H₁₅FN₂O₅ 

Downstream Products

• 66892-34-0 6-fluoro-4-chromanone 
• 90477-45-5 6-fluoro-4-iminochlorochromane 
• 67146-05-8 sorbinil 
• 99599-58-3 6-fluoro-1'-[3-(4-phenylpiperidino)propyl]spiro[chroman-4,4'-imidazolidine]-2',5'-dione 
• 90477-46-6 (RS)-4-amino-6-fluorochroman-4-carboxylic acid 

Relevant articles and documents

USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS

The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula

Lipase-catalyzed resolution of 5,5-disubstituted hydantoins

Chiral non-racemic 5,5-disubstituted hydantoins were prepared by lipase-catalyzed enantioselective hydrolyses of their N-acyloxymethyl groups or esterification of their N-hydroxymethyl groups.

Process for the production of asymmetric hydantoins

An improved process for preparing (4S)-6-fluorospiro-[chroman-4,4''-imidazolidine]-2'',5''-dione (sorbinil) or its (2R)-methyl derivative (2-methylsorbinil) is disclosed herein, starting from p-fluorophenol in each instance. The final products obtained ha