697287-41-5 Usage
Description
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide is a complex organic compound characterized by its white to off-white solid appearance. It is a potent and efficacious KCNQ2 opener, which plays a significant role in modulating neuronal hyperexcitability.
Uses
1. Used in Pharmaceutical Applications:
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide is used as a potent KCNQ2 opener for inhibiting induced hyperexcitability of rat hippocampal neurons. Its application in this field is due to its ability to reduce neuronal hyperexcitability, which can be beneficial in treating neurological disorders associated with abnormal neuronal activity.
2. Used in Neuroscientific Research:
In the field of neuroscience, (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide serves as a valuable tool for studying the role of KCNQ2 channels in neuronal function and their potential as therapeutic targets for various neurological conditions.
3. Used in Drug Development:
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide can be utilized in the development of new drugs targeting KCNQ2 channels, which may have applications in treating epilepsy, migraines, and other conditions characterized by neuronal hyperexcitability.
4. Used in Chemical Synthesis:
As a complex organic molecule, (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide may also find use in chemical synthesis for creating novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 697287-41-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,7,2,8 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 697287-41:
(8*6)+(7*9)+(6*7)+(5*2)+(4*8)+(3*7)+(2*4)+(1*1)=225
225 % 10 = 5
So 697287-41-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H25FN2O2/c1-16(25-23(27)11-9-18-4-2-3-5-20(18)24)19-8-10-22-21(14-19)26(12-13-28-22)15-17-6-7-17/h2-5,8-11,14,16-17H,6-7,12-13,15H2,1H3,(H,25,27)/b11-9+/t16-/m0/s1
697287-41-5Relevant articles and documents
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons
Wu, Yong-Jin,Boissard, Christopher G.,Chen, Jie,Fitzpatrick, William,Gao, Qi,Gribkoff, Valentin K.,Harden, David G.,He, Huan,Knox, Ronald J.,Natale, Joanne,Pieschl, Rick L.,Starrett Jr., John E.,Sun, Li-Qiang,Thompson, Mark,Weaver, David,Wu, Dedong,Dworetzky, Steven I.
, p. 1991 - 1995 (2007/10/03)
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide ((S)-2) was identified as a potent and efficacious KCNQ2 opener. This compound demonstrated significant activity in reducing neuronal hyperexcitabil
