69729-07-3

Basic information

• Product Name: L-Leucine, N-[N-(N-glycylglycyl)-L-phenylalanyl]-, phenylmethyl ester
• CAS NO: 69729-07-3
• Molecular Formula: C26H34N4O5
• Molecular Weight: 482.58
• Mol File: 69729-07-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[N-(N-glycylglycyl)-L-phenylalanyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[N-(N-glycylglycyl)-L-phenylalanyl]-, phenylmethyl ester(69729-07-3)
• EPA Substance Registry System: L-Leucine, N-[N-(N-glycylglycyl)-L-phenylalanyl]-, phenylmethyl ester(69729-07-3)

Safety Data

• Hazardous Substances Data: 69729-07-3(Hazardous Substances Data)

Upstream product

• 69729-14-2 benzyl ester of N-tert-butoxycarbonylglycylglycylphenylalanylleucine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 160617-39-0 Fmoc-Gly-Phe-Leu-OBzl 
• 103321-61-5 Fmoc-Phe-Leu-OBzl 
• 73994-89-5 (S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate 
• 103321-57-9 2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride 
• 63649-15-0 L-phenylalanyl-L-leucine benzyl ester 
• 124482-87-7 Fmoc-Gly-Gly-Phe-Leu-OBzl 
• 132090-36-9 Boc₂-Gly-Gly-Phe-Leu-OBzl 
• 98908-58-8 Z(OMe)-Gly-Gly-Phe-Leu-OBzl 
• 103321-49-9 9H-fluoren-9-ylmethyl (2-chloro-2-oxoethyl)carbamate 
• 80089-22-1 L-leucine (phenylmethyl)ester 
• 73994-89-5 2-[2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid benzyl ester 

Downstream Products

• 69729-16-4 N-benzyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine benzyl ester 
• 88099-29-0 2-[2-(2-{2-[3-(4-Benzyloxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid benzyl ester 
• 100930-01-6 Tyr-Gly-Gly-Phe-Leu formate 
• 58822-25-6 Leu-enkephalin 
• 130245-55-5 Z-Tyr(SO₃H)-Gly-Gly-Phe-Leu-OBzl 
• 80632-52-6 sulfated [Leu⁵]-enkephalin 
• 60254-86-6 Tyr-Gly-Gly-Phe-Leu 
• 948314-83-8 Leu⁵-Eukephalin 
• 88099-29-0 Fmoc-Tyr(Bzl)-Gly-Gly-Phe-Leu-OBzl 
• 148797-62-0 Adoc₂-Tyr(Adoc)-Gly-Gly-Phe-Leu-OBzl 
• 74974-13-3 benzyl ester of N-benzyloxycarbonyl-O-benzyltyrosylglycylglycylphenylalanylleucine 
• 132090-37-0 Boc₂-Tyr(Bzl)-Gly-Gly-Phe-Leu-OBzl 

Relevant articles and documents

Method of producing peptide

The present invention is related to a method of producing a peptide, characterized in contacting a reaction mixture with a base after a condensation reaction to hydrolyze while a basic condition is maintained until a ratio of a remaining unreacted active

Synthesis of [Leu5]enkephalin using Fmoc-Amino Acid Chlorides/KOAt

The coupling of Fmoc-amino acid chlorides can be mediated by the potassium salt of 1-hydroxy-7-azabenzotriazole. Thus the synthesis of [Leu5]enkephalin has been accomplished in good yield and purity.

Synthesis and application of N,N-bis-(1-adamantyloxycarbonyl) amino acids.

The preparation of novel bis-(1-adamantyloxycarbonyl) amino acid derivatives has been undertaken and their properties studied. Among them, the p-nitrophenyl esters were subsequently applied to the stepwise synthesis of Leu-enkephalin. In the last coupling step, some hydantoin formation was encountered but it could be nearly completely overcome by working with more concentrated solution. The preparation of a tyrosine derivative presented special problems owing to the existence of the phenolic group in the precursor. The relative stability of 1-adamantyloxycarbonyl as N- and O-protecting groups was also studied.