6976-20-1

Basic information

• Product Name: 1-(biphenyl-4-yl)-2-methylpropan-1-one
• CAS NO: 6976-20-1
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.2976
• Mol File: 6976-20-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 348.5°C at 760 mmHg
• Flash Point: 149.4°C
• Density: 1.021g/cm³
• Vapor Pressure: 5E-05mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 1-(biphenyl-4-yl)-2-methylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(biphenyl-4-yl)-2-methylpropan-1-one(6976-20-1)
• EPA Substance Registry System: 1-(biphenyl-4-yl)-2-methylpropan-1-one(6976-20-1)

Safety Data

• Hazardous Substances Data: 6976-20-1(Hazardous Substances Data)

Usage

General Description

1-(biphenyl-4-yl)-2-methylpropan-1-one is a chemical compound with the molecular formula C15H14O. It is a ketone derivative with a substituted biphenyl group and a methyl group attached to the carbon chain. 1-(biphenyl-4-yl)-2-methylpropan-1-one may have various applications in organic synthesis, pharmaceuticals, and industrial processes due to its structural properties and potential reactivity. It is important to handle this compound with caution and follow proper safety protocols, as it may pose health and environmental risks if not handled properly.

Upstream product

• 92-52-4 biphenyl 
• 79-30-1 isobutyryl chloride 
• 37940-57-1 1-biphenyl-4-yl-propan-1-one 
• 77-78-1 dimethyl sulfate 
• 2403-57-8 1-(2-methylprop-1-en-1-yl)pyrrolidine 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 15365-60-3 (CO)5Cr(CNC(O)CH(CH₃)2) 
• 49660-93-7 4'-bromoisobutyrophenone 
• 100-58-3 phenylmagnesium bromide 
• 720-75-2 methyl 4-phenylbenzoate 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 170938-13-3 α-vinyl-(4-phenyl-phenyl)methanol 

Downstream Products

• 720-75-2 methyl 4-phenylbenzoate 
• 1005213-48-8 2-(4-phenylphenylene)-3,3-dimethyl-3H-indole 
• 6301-56-0 ethyl 4-phenylbenzoate 
• 71945-53-4 benzyl [1,1’-biphenyl]-4-carboxylate 
• 1206829-67-5 2-nitro-5a-(4-phenylphenylene)-6,6-dimethyl-5a,6-dihydro-12H-indolo[2,1-b][1,3]benzooxazine 

Relevant articles and documents

Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol

One-pot synthesis of α-methyl ketones starting from 1,3-diaryl propenols or 1-aryl propenols and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by commercially available Pd(OAc)2 with H2O as the only by-product. Mechanistic studies and deuterium labelling experiments indicate the involvement of isomerization of allyl alcohol followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.

Rigid Multidimensional Alkoxyamines: A Versatile Building Block Library

Since the discovery of the “living” free-radical polymerization, alkoxyamines were widely used in nitroxide-mediated polymerization (NMP). Most of the known alkoxyamines bear just one functionality with only a few exceptions bearing two or more alkoxyamine units. Herein, we present a library of novel multidimensional alkoxyamines based on commercially available, rigid, aromatic core structures. A versatile approach allows the introduction of different sidechains which have an impact on the steric hindrance and dissociation behavior of the alkoxyamines. The reaction to the alkoxyamines was optimized by implementing a mild and reliable procedure to give all target compounds in high yields. Utilization of biphenyl, p-terphenyl, 1,3,5-triphenylbenzene, tetraphenylethylene, and tetraphenyl-methane results in linear, trigonal, square planar, and tetrahedral shaped alkoxyamines. These building blocks are useful initiators for multifold NMP leading to star-shaped polymers or as a linker for the nitroxide exchange reaction (NER), to obtain dynamic frameworks with a tunable crosslinking degree and self-healing abilities.

One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization-Methylation

A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield).