69821-03-0Relevant articles and documents
A Synthesis of Natural α-Tocopherol Intermediate
Sugai, Takeshi,Watanabe, Naoyuki,Ohta, Hiromichi
, p. 371 - 376 (2007/10/02)
(S)-(-)-6-Hydroxy-2,5,7,8-tetramethyl-2-chromanmethanol, an intermediate of natural α-tocopherol was synthesized from (S)-2-benzyloxy-2-methyl-4-pentenoic acid, which was obtained by the enzymatic hydrolysis of the corresponding racemic methyl ester.
ASYMMETRIC SYNTHESIS OF A CHROMAN DERIVATIVE (VITAMIN E PRECURSOR)
Sakito, Yoji,Suzukamo, Gohfu
, p. 4953 - 4954 (2007/10/02)
Chromanmethanol 2, a chiral intermediate for the synthesis of α-tocopherol 1, is prepared from α-hydroxy aldehyde 5, which is obtained by an asymmetric synthesis in over 95percent ee.