69843-13-6

Basic information

• Product Name: 1-METHYL-1H-PYRAZOL-4-YLAMINE
• Synonyms: ART-CHEM-BB B022860;ASINEX-REAG BAS 13529566;1-METHYL-1H-PYRAZOL-4-YLAMINE;AKOS PAO-0224;AKOS B022860;TIMTEC-BB SBB009607;1-methyl-1H-pyrazol-4-amine hydrochloride;4-Amino-1-methylpyrazole
• CAS NO: 69843-13-6
• Molecular Formula: C₄H₇N₃
• Molecular Weight: 97.12
• EINECS: 1592732-453-0
• Mol File: 69843-13-6.mol
• Article Data: 40

Chemical Properties

• Melting Point: 47-50℃
• Boiling Point: 231.4 °C at 760 mmHg
• Flash Point: >110 °C
• Appearance: /
• Density: 1.141 g/mL at 25 °C
• Vapor Pressure: 0.0624mmHg at 25°C
• Refractive Index: n20/D1.556
• Storage Temp.: ?20°C
• PKA: 3.70±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-METHYL-1H-PYRAZOL-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-PYRAZOL-4-YLAMINE(69843-13-6)
• EPA Substance Registry System: 1-METHYL-1H-PYRAZOL-4-YLAMINE(69843-13-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 69843-13-6(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazol-4-ylamine is a chemical entity primarily recognized in chemical and pharmaceutical research. 1-Methyl-1H-pyrazol-4-ylamine consists of a pyrazole core structure, which is a heterocyclic aromatic ring system composed of three carbon atoms and two nitrogen atoms, with an amine and a methyl group attached. Pyrazole derivatives, to which this compound belongs, are often studied for their diverse range of biological activities, giving 1-Methyl-1H-pyrazol-4-ylamine potential as a precursor for drug development. However, specific properties or uses for this compound may vary and should be determined by a qualified chemist.

InChI:InChI=1/C4H7N3/c1-7-3-4(5)2-6-7/h2-3H,5H2,1H3

Upstream product

• 3994-50-1 1-methyl-4-nitropyrazole 
• 15803-02-8 4-bromo-1-methyl-1H-pyrazole 
• 2075-46-9 4-nitro-1H-pyrazole 
• 74-88-4 methyl iodide 
• 54210-32-1 1-methyl-3-nitro-1H-pyrazole 

Downstream Products

• 127107-23-7 1-methyl-1H-pyrazol-4-amine monohydrochloride 
• 499792-91-5 7-(4-chlorobenzyl)-1-methyl-5,6,7,8-tetrahydro-1H-pyrazolo[4,3-b]quinolin-9-ol 
• 948572-95-0 N-(1-methylpyrazol-4-yl)-2,4-dinitrobenzenesulphonamide 
• 1159601-85-0 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(1-methyl-1H-pyrazol-4-yl)-nicotinamide 
• 1159602-21-7 6-[3-(4-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(1-methyl-1H-pyrazol-4-yl)-nicotinamide 
• 1201934-31-7 2-((5-fluoro-2-((1-methylpyrazol-4-yl)amino)-4-pyridyl)amino)-N-methyl-benzamide 
• 1246924-17-3 6-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-(1-methyl-1H-pyrazol-4-yl)-nicotinamide 
• 1246924-25-3 6-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-(1-methyl-1H-pyrazol-4-yl)-nicotinamide 
• 1246924-40-2 6-[3-(3,4-Difluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-(1-methyl-1H-pyrazol-4-yl)-nicotinamide 
• 1001500-53-3 4-isothiocyanato-1-methyl-1H-pyrazole 
• 1258557-54-8 4-[2-({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}amino)phenyl]tetrahydro-2H-pyran-4-ol 
• 1285514-20-6 5-bromo-N-(1-methyl-1H-pyrazol-4-yl)-2-[(phenylmethyl)oxy]benzamide 
• 1285514-48-8 N-(1-methyl-1H-pyrazol-4-yl)-2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzamide 
• 1296307-10-2 N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine 

Relevant articles and documents

Light-Triggered, Non-Centrosymmetric Self-Assembly of Aqueous Arylazopyrazoles at the Air–Water Interface and Switching of Second-Harmonic Generation

Trans-p-methoxy arylazopyrazole spontaneously forms non-centrosymmetric polar crystals, which reversibly undergo liquefaction upon photoisomerization to the cis-isomer. This liquid cis-isomer has a large electric dipole moment and is highly soluble in water (solubility up to ≈58 mM), which is remarkably higher than that of the trans-isomer (690 μM). Vis-light illumination of the aqueous cis-isomer generates macroscopically oriented, non-centrosymmetric crystals at the air–water interface. Polar crystals are also formed in sandwich glass cells (spacing, 20 μm) upon photo-induced crystallization of the liquid cis-isomer. The trans-crystals thus formed showed second harmonic generation (SHG) whose intensity is switched on/off in response to the photo-induced phase transition.

Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation

We describe a scalable method for preparing an aminopyrazole building block using copper-catalyzed amidation with acetamide as an ammonia surrogate. This procedure provides an alternative to the standard nitration/reduction sequence and avoids energetic intermediates, specialized hydrogenation equipment, and potentially genotoxic impurities that arise from nitro reduction. The chemistry has been successfully scaled to produce >50 kg of the target compound and demonstrate the viability of this alternative route.

Alkynyl pyrimidine or alkynyl pyridine compound as well as composition and application thereof

The invention relates to alkynyl pyrimidine or alkynyl pyridine compounds represented by a formula (I) or pharmaceutically acceptable salts, isomers, solvates, crystals or prodrugs thereof. The invention also discloses a pharmaceutical composition contain