6998-83-0Relevant articles and documents
Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions
Zhou, Yuntao,Piergentili, Irene,Hong, Jennifer,Helm, Michelle P. Van Der,MacChione, Mariano,Li, Yao,Eelkema, Rienk,Luo, Sanzhong
supporting information, p. 6035 - 6040 (2020/10/02)
Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermediate. This new type of catalyst showed up to 15-fold rate enhancement over the traditional anilinecatalyzed reaction at neutral conditions. The identified indoline catalyst was successfully applied in hydrogel formation.
A flexible solution to anion transport: Powerful anionophores based on a cyclohexane scaffold
Cooper, James A.,Street, Steven T. G.,Davis, Anthony P.
supporting information, p. 5609 - 5613 (2014/06/10)
Transmembrane anion carriers (anionophores) have potential for biological activity, including the treatment of channelopathies such as cystic fibrosis. A new family of anionophores has been synthesized, in which three thiourea groups are mounted on a cyclohexane-based scaffold. Though conceptually related to earlier polycyclic systems, these molecules are simpler and far more accessible. Preorganization is somewhat reduced compared to earlier systems, and anion affinities are correspondingly lower. However, transport activities set new records. This surprising performance suggests a role for controlled flexibility in the design of transmembrane anion carriers. Speedy shuttling: New anionophores were developed which are simpler and far more accessible than conceptually related earlier systems. They are also less preorganized and anion affinities are lower (as expected), but transport activities set new records. This surprising performance suggests a role for controlled flexibility in the design of transmembrane anion carriers.
Synthesis of 3,5,12-Triazawurtzitanes ( 3,5,12-Triazatetracyclo2,604,9>dodecanes
Nielsen, Arnold T.,Christian, Stephen L.,Moore, Donald W.,Gilardi, Richard D.,George, Clifford F.
, p. 1656 - 1662 (2007/10/02)
The first examples of 3,5,12-triazawurtzitanes (3,5,12-triazatetracyclo2,604,9>dodecanes are described. cis, cis - 1.3.5-Triformylcyclohexane (8) has been synthesised by Swern oxidation of cis, cis - 1.3.5-tris(hydroxymethyl