7004-98-0 Usage
Originator
Stimovul,Organon,W. Germany,1976
Uses
Anterior pituitary activator.
Manufacturing Process
Reduction of 16-keto-17(α)-hydroxyestratrienol-3-methyl to 16,17-
dihydroxyestratrienol-3-methyl ether: A solution of 800 mg of the alpha ketol
methyl ether in 100 cc of ethanol and 10 cc of acetic acid was carefully
maintained at 40°C (water bath), and 200 g of freshly prepared sodium
amalgam (2%) were added in small pieces with efficient swirling. Before all ofthe amalgam had been added, a precipitation of sodium acetate occurred, and
at this point an additional 100 cc of 50% acetic acid were added. After all the
reducing agent had been added, the mixture was transferred to a separatory
funnel with ether and water. The mercury plus aqueous phase was separated,
after partitioning, from the ether; the latter may be further washed with
water, with 0.5N sodium hydroxide, and again with water to purify the alpha
glycol. Evaporation of the ethereal phase yielded a crystalline residue of the
isomeric transoid (16(β),17(α)-dihydroxy-steroid-3-methyl ether and cisoid
16(α),17(α)dihydroxy-steroid-3-methyl ether.
Therapeutic Function
Anterior pituitary activator
Check Digit Verification of cas no
The CAS Registry Mumber 7004-98-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,0 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 7004-98:
(6*7)+(5*0)+(4*0)+(3*4)+(2*9)+(1*8)=80
80 % 10 = 0
So 7004-98-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H26O3/c1-19-8-7-14-13-6-4-12(22-2)9-11(13)3-5-15(14)16(19)10-17(20)18(19)21/h4,6,9,14-18,20-21H,3,5,7-8,10H2,1-2H3
7004-98-0Relevant articles and documents
Steroids. LXIX. Cyclisation Reactions of Vicinal Substituted Halogen Carbamoyloxy Steroids
Ponsold, K.,Grosse, P.
, p. 801 - 818 (2007/10/02)
Vicinal halogen urethanes of the cholestane, androstane and estratriene series react by heating under solvolytic conditions to cyclic carbonates of the corresponding cis-diols.By heating under basic conditions the same compounds react preferably to 2-oxazolidinones and if the basic conditions are strong enough by hydrolysis of the oxazolidinones to cis-amine alcohols too.Connections between the nature of the substituent at the urethane group or the steric arrangement of the vicinal groups on one hand and the reactivity to ring closure on the other hand are presented.
