7010-86-8

Basic information

• Product Name: 4-Methoxy-N-methylbenzenesulphonamide
• Synonyms: 4-Methoxy-N-methylbenzenesulphonamide;4-methoxy-N-methylbenzenesulfonamide;BenzenesulfonaMide,4-Methoxy-N-Methyl-;4-(N-Methylsulphamoyl)anisole
• CAS NO: 7010-86-8
• Molecular Formula: C₈H₁₁NO₃S
• Molecular Weight: 201.24284
• Mol File: 7010-86-8.mol
• Article Data: 29

Chemical Properties

• Melting Point: 98-100
• Boiling Point: 324.4 °C at 760 mmHg
• Flash Point: 150 °C
• Appearance: /
• Density: 1.226 g/cm³
• Vapor Pressure: 0.000246mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 4-Methoxy-N-methylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-N-methylbenzenesulphonamide(7010-86-8)
• EPA Substance Registry System: 4-Methoxy-N-methylbenzenesulphonamide(7010-86-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 7010-86-8(Hazardous Substances Data)

Usage

General Description

4-Methoxy-N-methylbenzenesulphonamide is a chemical compound with the molecular formula C8H11NO3S. It is derived from the sulphonamide class of compounds and contains a methoxy group attached to a benzene ring. This chemical is used in medicinal and pharmaceutical applications as a reagent and intermediate for the synthesis of various compounds. It has been studied for its potential use in the treatment of various medical conditions, including cancer and infectious diseases, due to its pharmacological properties. Additionally, it is also used in the chemical industry for the production of other organic compounds.

InChI:InChI=1/C8H11NO3S/c1-9-13(10,11)8-5-3-7(12-2)4-6-8/h3-6,9H,1-2H3

Upstream product

• 86674-09-1 C₈H₁₀N₂O₅S 
• 210820-71-6 4-methoxy-benzenesulfonic acid-(methyl-nitroso-amide) 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 74-89-5 methylamine 
• 100-61-8 N-methylaniline 
• 108-30-5 succinic acid anhydride 
• 1129-26-6 4-methoxybenzene sulfonamide 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 6140-09-6 sodium 4-methoxy-benzenesulfonate 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 593-51-1 methylamine hydrochloride 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 

Downstream Products

• 210820-71-6 4-methoxy-benzenesulfonic acid-(methyl-nitroso-amide) 
• 53119-88-3 N-(2-Hydroxy-1-phenyl-ethyl)-4-methoxy-N-methyl-benzenesulfonamide 
• 53119-86-1 [(4-Methoxy-benzenesulfonyl)-methyl-amino]-phenyl-acetic acid methyl ester 
• 53119-84-9 (4-Methoxy-phenyl)-[methyl-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester 
• 52260-06-7 N-Methyl-N-vinyl-p-methoxybenzolsulfonamid 
• 929205-76-5 N-methyl-2-iodo-4-methoxy-benzenesulfonamide 
• 929205-79-8 2-(4-hydroxy-but-1-ynyl)-4-methoxy-N-methyl-benzenesulfonamide 
• 929205-80-1 2-(5-hydroxy-pent-1-ynyl)-4-methoxy-N-methyl-benzenesulfonamide 
• 206258-26-6 4-[methyl-(4-methoxy-benzenesulfonyl)-amino]-8-bromo-quinoline-3-carboxylic acid 
• 52260-11-4 4-Methoxy-N-methyl-N-(1-phenyl-vinyl)-benzenesulfonamide 
• 52260-08-9 N-[1-(4-Methoxy-phenyl)-vinyl]-4,N-dimethyl-benzenesulfonamide 
• 202751-64-2 N-[(2-iodophenyl)methyl]-N-methyl-4-methoxybenzenesulfonamide 
• 86674-09-1 C₈H₁₀N₂O₅S 

Relevant articles and documents

Copper-catalyzed oxidative methylation of sulfonamides by dicumyl peroxide

A novel and facile copper-catalyzed methylation of sulfonamides was herein demonstrated. The practical transformation took place readily under the oxidative conditions, and N-methyl amides (23 examples) were successfully furnished in high efficiency (up to 90% yields). Dicumyl peroxide was considered to act not only as the oxidant in the system, but also methyl donor for the methylation protocol.

Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate

An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl2]2 on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalysts for hydrogen autotransfer process.

Direct Introduction of Sulfonamide Groups into Quinoxalin-2(1H)-ones by Cu-Catalyzed C3-H Functionalization

Direct sulfonamidation of quinoxalin-2(1H)-one derivatives has been developed using a readily available Cu salt as the catalyst and inexpensive ammonium persulfate as the oxidant in moderate conditions. Owing to the feature of handy operation and good functional group tolerance, this method provides a convenient and efficient access to curative 3-sulfonamidated quinoxalin-2(1H)-one scaffolds.