70120-08-0 Usage
Description
α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile is an organic compound characterized by its unique molecular structure, featuring a benzene ring with a nitrile group, two methyl groups, and a phenylmethoxy substituent. α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile is known for its potential applications in the synthesis of various pharmaceutical agents and biologically active molecules.
Uses
Used in Pharmaceutical Industry:
α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile is used as a reagent for the preparation of BACE inhibitors and protein kinase C ligands. Its role in the synthesis of these compounds is crucial for the development of potential therapeutic agents targeting various diseases and conditions.
In the context of BACE inhibitors, α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile contributes to the development of drugs aimed at treating Alzheimer's disease by inhibiting the enzyme β-secretase (BACE), which is responsible for the production of amyloid-beta peptides. These peptides are known to form plaques in the brains of Alzheimer's patients, contributing to the progression of the disease.
On the other hand, protein kinase C ligands are involved in the modulation of cellular signaling pathways, which play a significant role in various physiological processes and disease mechanisms. α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile aids in the synthesis of these ligands, potentially leading to the development of drugs that can target specific protein kinase C isoforms and treat a range of diseases, including cancer, diabetes, and neurological disorders.
Overall, α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile is a valuable reagent in the pharmaceutical industry, with its applications extending to the development of novel therapeutic agents for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 70120-08-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,1,2 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 70120-08:
(7*7)+(6*0)+(5*1)+(4*2)+(3*0)+(2*0)+(1*8)=70
70 % 10 = 0
So 70120-08-0 is a valid CAS Registry Number.
70120-08-0Relevant articles and documents
NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS
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Paragraph 00291, (2016/01/12)
A compound according to Formula I: wherein R1, LA, GA, R2a, R2b, R3, R4, R5, and R6 are as described herein. The present invention relates to novel compound
Phenyl derivatives and methods of use
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Page/Page column 26, (2010/10/20)
Novel phenyl compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, genitourinary disorders, inflammation, glaucoma, auto-immune diseases, ischemic conditions, immune-related disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, and as an appetite stimulant.
A Cannabinoid Derived Prototypical Analgesic
Melvin, Lawrence S.,Johnson, M. Ross,Harbert, Charles A.,Milne, George M.,Weissman, Albert
, p. 67 - 71 (2007/10/02)
The synthesis and analgesic testing of 3-cyclohexanol (1) are described.Prior (SAR) studies led us to conclude that the pyran ring of 9-nor-9β-hydroxyhexahydrocannabinol (HHC) was not necessary for the expression of biological activity in this series of cannabinoids.Analysis of models and the use of molecular mechanics calculations suggested that a simpler compound, such as 1, would possess the biological activity of HHC.Compound 1 was prepared in nine steps from acetonitrile (2).Biological testing in five models of pain shows that compound 1 and morphine are equally potent as analgesics and demonstrates that the pyran ring of HHC is not necessary for biological activity.Further simplification of 1 was pursued by the synthesis of 4--2-pentanol (17), but this derivative exhibits significantly reduced analgesic activity.
