70171-70-9

Basic information

• Product Name: 1-(3-hydroxyphenyl)-3-propan-2-ylurea
• CAS NO: 70171-70-9
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.2304
• Mol File: 70171-70-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 318.3°C at 760 mmHg
• Flash Point: 146.3°C
• Density: 1.19g/cm³
• Vapor Pressure: 0.000196mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 1-(3-hydroxyphenyl)-3-propan-2-ylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-hydroxyphenyl)-3-propan-2-ylurea(70171-70-9)
• EPA Substance Registry System: 1-(3-hydroxyphenyl)-3-propan-2-ylurea(70171-70-9)

Safety Data

• Hazardous Substances Data: 70171-70-9(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. Urea derivative

Explanation

A urea derivative is a compound that contains a urea group (NH2-C(=O)-NH-) as part of its structure.
3. Phenol ring

Explanation

The phenol ring is a six-membered aromatic ring with a hydroxyl group (-OH) attached to it.
4. Propan-2-yl group

Explanation

A propan-2-yl group is a three-carbon alkyl group (-CH(CH3)2) attached to the nitrogen atom of the urea group.
5. Potential applications in pharmaceuticals

Explanation

The compound may have properties that make it useful in the development of new drugs or drug formulations.
6. Organic synthesis

Explanation

The compound can be used as a building block or intermediate in the synthesis of other organic compounds.
7. Medical research

Explanation

Further investigation and study of the compound may reveal its potential benefits and applications in various fields of medical research.
8. Structure

Explanation

The compound consists of a urea group attached to a phenol ring, with a propan-2-yl group attached to the nitrogen atom of the urea group.
9. Chemical properties

Explanation

The compound's chemical properties, such as reactivity, solubility, and stability, may be influenced by its molecular structure and functional groups.
10. Physical properties

Explanation

The compound's physical properties, such as melting point, boiling point, and density, may be relevant to its potential applications and handling.

Upstream product

• 787591-43-9 2-(3-isocyanatophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 75-31-0 isopropylamine 
• 210907-84-9 3-aminophenylboronic acid pinacolate 

Downstream Products

• 70171-10-7 (2-Cyano-ethyl)-(3-methoxy-phenyl)-carbamic acid 3-(3-isopropyl-ureido)-phenyl ester 
• 70171-05-0 N-(2-cyanoethyl)-3-methylcarbanilic acid-[3-(3-isopropylureido)-phenyl]-ester 
• 70171-29-8 Cyanomethyl-m-tolyl-carbamic acid 3-(3-isopropyl-ureido)-phenyl ester 
• 70171-19-6 Cyanomethyl-phenyl-carbamic acid 3-(3-isopropyl-ureido)-phenyl ester 
• 70171-04-9 N-(2-cyanoethyl)-carbanilic acid-[3-(3-isopropylureido)-phenyl]-ester 

Relevant articles and documents

Synthesis and antitumor activity of novel pyridino[2,3-d]pyrimidine urea derivatives

A series of novel N-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)pyrrolidine-1-carboxamide and 1-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)-3-propylurea derivatives were synthesized. Their antitumor activities against human breast carcinoma cells (MCF-7) and human colon cancer cells (HCT-116) in vitro were evaluated, using sorafenib as a positive control drug. Anticancer bioassays indicated that several compounds exhibited appreciable anticancer activity against MCF-7 and HCT-116 cells. Particularly, compounds 9g and 8b demonstrated the most significant inhibitory effect against HCT-116 and MCF-7 cells, with inhibition ratios of 25.56% and 26.46%, respectively. Additionally, the synthesized pyridine[2,3-d]pyrimidine derivatives containing a urea group moieties exhibited antitumor activities against MCF-7 and HCT-116 cells in vitro.