70199-60-9Relevant articles and documents
4-methoxymethylpyridine synthesis method
-
Paragraph 0023; 0026; 0028; 0029; 0032; 0033; 0036, (2020/02/04)
The invention relates to the field of organic chemistry, particularly to a 4-methoxymethylpyridine synthesis method, which comprises: carrying out a bromination reaction on 4-methylpyridine as a raw material to obtain 4-bromo-methylpyridine; carrying out a reaction on the 4-bromo-methylpyridine and trimethylamine to obtain (4-pyridylmethyl)trimethyl ammonium bromide; and dissolving the (4-pyridylmethyl)trimethyl ammonium bromide in methanol, adding sodium methoxide, and carrying out heating reflux for 1 h in the presence of nitrogen to obtain the 4-methoxymethylpyridine. According to the invention, by using the synthesis method, 4-methylpyridine is used as the raw material, and is subjected to the bromination reaction to obtain 4-bromo-methylpyridine, the 4-bromo-methylpyridine reacts withtrimethylamine to obtain (4-pyridylmethyl)trimethyl ammonium bromide, and finally the (4-pyridylmethyl)trimethyl ammonium bromide reacts with sodium methoxide to obtain the 4-methoxymethylpyridine; and the synthesis method is high in total yield, cheap in raw material price, short in reaction time, mild in condition and simple in process operation.
Synthesis of Diarylated 4-Pyridylmethyl Ethers via Palladium-Catalyzed Cross-Coupling Reactions
Ablajan, Keyume,Panetti, Grace B.,Yang, Xiaodong,Kim, Byeong-Seon,Walsh, Patrick J.
supporting information, p. 1927 - 1932 (2017/06/09)
The direct arylation of weakly acidic sp3-hybridized C–H bonds via deprotonated cross-coupling processes (DCCP) is a challenge. Herein, a palladium(NIXANTPHOS)-based catalyst for the monoarylation of 4-pyridylmethyl 2-aryl ethers to generate di
Synthesis of alkyl heteryl ethers from acetates under interphase catalysis conditions in a liquid/solid system
Abele,Abele,Gaukhman,Lukevics
, p. 40 - 43 (2007/10/03)
The reaction of acetates of heterocyclic alcohols with alkyl halides in the two-phase catalytic system of solid KOH/C6H6/18-crown-6 at room temperature leads selectively to the formation of the corresponding heterocyclic ethers in 32-93% yield. 1998 Plenum Publishing Corporation.