70310-94-0Relevant articles and documents
Sterol regulatory element binding protein and acidic nucleoplasm DNA binding protein-1 inhibitor, preparation method and application thereof
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Paragraph 0060-0063; 0077-0079, (2020/07/13)
The invention discloses a compound which is shown as formula I and can inhibit sterol regulatory element binding protein (Srebp) and acidic nucleoplasm DNA binding protein-1 (And-1, WDHD1), a preparation method and application thereof. RT-PCR (reverse transcription-polymerase chain reaction) and immunoblotting experiments show that the compound can remarkably reduce the expression of a Srebp downstream gene SCD-1 and inhibit the activity of And-1 protein. Further experiments show that the compound has a proliferation inhibition effect on various tumor cells. The compound shown as formula I isexpected to become a novel anti-tumor drug and a tumor chemoradiotherapy sensitizing drug.
An efficient and convenient synthesis of 5-formylsalicylaldehyde
Lee, Seung Hwan,Cho, Young Jin,Bae, Jong Woo,Yoon, Cheol Min
, p. 1003 - 1008 (2007/10/03)
5-Formylsalicylaldehyde 1, which is a key intermediate of spiropyran dye and a recently developed insulin sensitivity enhancer (ISE) compounds, was prepared from 5-iodosalicylaldehyde by the palladium-catalyzed coupling reaction with ethyl acrylate follow
