7035-02-1

Basic information

• Product Name: 2-Methoxybenzyl chloride
• Synonyms: 2-METHOXYBENZYL CHLORIDE;2-(CHLOROMETHYL)ANISOLE;2-Methoxybenzyl chloride, stabilized, 98%;Benzene, 1-(chloromethyl)-2-methoxy-;o-Methoxybenzylchloride;2-METHOXYBENZYL CHLORIDE (50% BY WEIGHT IN METHYLENE CHLORIDE);2-Methoxybenzyl chloride, 98%, stabilized;2-Methoxybenzyl chloride2-(Chloromethyl)anisole
• CAS NO: 7035-02-1
• Molecular Formula: C₈H₉ClO
• Molecular Weight: 156.61
• EINECS: 230-312-4
• Product Categories: Aromatic Halides (substituted);Aromatic compound
• Mol File: 7035-02-1.mol
• Article Data: 37

Chemical Properties

• Melting Point: 28.3-29.8 °C(lit.)
• Boiling Point: 122-124 °C26 mm Hg(lit.)
• Flash Point: 210 °F
• Appearance: /
• Density: 1.125 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.219mmHg at 25°C
• Refractive Index: n20/D 1.549(lit.)
• Storage Temp.: Refrigerator (+4°C)
• CAS DataBase Reference: 2-Methoxybenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxybenzyl chloride(7035-02-1)
• EPA Substance Registry System: 2-Methoxybenzyl chloride(7035-02-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36-45-36/37/39
• RIDADR: UN 3261 8/PG 3
• WGK Germany: 3
• HazardClass: CORROSIVE
• Hazardous Substances Data: 7035-02-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to yellow liquid

Uses

1-(Chloromethyl)-2-methoxy-benzene is used in the synthesis of indole derivatives in the preparation of anti-cancer agents. Also used to synthesize potent and selective antagonists for the receptor CX3XR1 involved in the treatment of multiple sclerosis.

InChI:InChI=1/C8H9ClO/c1-10-8-5-3-2-4-7(8)6-9/h2-5H,6H2,1H3

Upstream product

• 612-16-8 (2-methoxyphenyl)methanol 
• 1801-77-0 oxovanadium(V) ethoxydichloride 
• 99522-22-2 o-(trimethylsilylmethyl)benzyl alcohol 
• 7647-01-0 hydrogenchloride 
• 50-00-0 formaldehyd 
• 7732-18-5 water 
• 100-66-3 methoxybenzene 
• 578-58-5 2-methylmethoxybenzene 
• 7782-50-5 chlorine 
• 614-71-1 2-ethoxytoluene 
• 135-02-4 ortho-anisaldehyde 
• 579-75-9 2-Methoxybenzoic acid 
• 7335-26-4 ethyl 2-methoxybenzoate 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 64988-06-3 ethyl 2-methoxybenzyl ether 
• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 54787-20-1 4-(2-methoxy-phenyl)-3-phenyl-butan-2-one 
• 14310-34-0 1,2-bis(2-methoxyphenyl)ethane 
• 54943-17-8 5-(2-methoxy-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine 
• 42784-65-6 5-(2-hydroxy-ethyl)-3-(2-methoxy-benzyl)-4-methyl-thiazolium; chloride 
• 4071-09-4 2-<2-Methoxy-benzyl>-2-benzoyl-propan 
• 55142-91-1 5-(2-methoxy-benzyl)-4,5,6,7-tetrahydro-furo[3,2-c]pyridine 
• 99810-09-0 3-chloropropyl o-methoxybenzyl sulfide 
• 90252-81-6 3-(2-Methoxy-benzyl)-but-3-enoic acid 
• 77029-06-2 1-(2-Methoxy-phenyl)-2-naphthalen-1-yl-propan-2-ol 
• 32298-34-3 (2-methoxy benzyl) succinic acid 
• 34602-11-4 2-methoxybenzyl 4'-tolyl sulfone 
• 113756-62-0 8-benzyloxy-N-benzoyl-1-(2'-methoxybenzyl)-1,2-dihydro-7-methoxyisoquinoline-1-carbonitrile 

Relevant articles and documents

Mechanism of solvolysis of substituted benzyl chlorides in aqueous ethanol

The mechanism of solvolyses of activated ortho-, meta- and para-substituted benzyl chlorides in aqueous ethanol has been studied by using the Hammett-Brown and Yukawa-Tsuno treatments as well as by correlating logarithms of solvolysis rate constants with relative stabilities of corresponding benzyl carbocations in water calculated at the IEFPCM-M06–2X/6-311+G(3df,3pd) level of theory. Benzyl chlorides containing strong conjugative electron-donors in the para-position solvolyze by the SN1 mechanism, whereas other activated benzyl chlorides solvolyze by the SN2 mechanism via loose transition states.

Pyrrolopyrazole derivative, preparation method and medical application thereof

The invention relates to pyrrolopyrazole derivative, a preparation method and application thereof in medicines. Specifically, the invention relates to a new pyrrolopyrazole derivative as shown in a general formula (I), a preparation method and application of the pyrrolopyrazole derivative or a pharmaceutical composition containing the pyrrolopyrazole derivative as a therapeutic agent, particularlyas a gastric acid secretion inhibitor and potassium-competitive acid blockers (P-CABs) in biological medicines. Specifically, the substituents (R1, R2, R3 and R4) in the general formula (I) are the same as the definitions in the specification.

Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents

As a continuation of earlier works, a series of novel quinazolinone derivatives (5a-s) were synthesized and evaluated for their in vitro anti-HBV and anti-hepatocellular carcinoma cell (HCC) activities. Among them, compounds 5j and 5k exhibited most potent inhibitory effect on HBV DNA replication in both drug sensitive and resistant (lamivudine and entecavir) HBV strains. Interestingly, besides the anti-HBV effect, compound 5k could significantly inhibit the proliferation of HepG2, HUH7 and SK- cells, with IC50 values of 5.44, 6.42 and 6.75 μM, respectively, indicating its potential anti-HCC activity. Notably, the in vitro anti-HCC activity of 5k were more potent than that of positive control 5-fluorouracil and sorafenib. Further studies revealed that compound 5k could induce HepG2 cells apoptosis by dose-dependently upregulating Bad and Bax expression and decreasing Bcl-2 and Bcl-xl protein level. Considering the potent anti-HBV and anti-HCC effect, compound 5k might be a promising lead to develop novel therapeutic agents towards HBV infection and HBV-induced HCC.